RGS6

Regulator of G-protein signaling 6
PDB rendering based on 2es0.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2ES0​
Identifiers
Symbols	RGS6 ; GAP
External IDs	OMIM: 603894 MGI: 1354730 HomoloGene: 68385 GeneCards: RGS6 Gene
Gene ontology Molecular function • signal transducer activity • GTPase activator activity • protein binding Cellular component • cytoplasm • heterotrimeric G-protein complex • plasma membrane Biological process • G-protein coupled receptor signaling pathway • regulation of G-protein coupled receptor protein signaling pathway • intracellular signal transduction • termination of G-protein coupled receptor signaling pathway • positive regulation of GTPase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9628	50779
Ensembl	ENSG00000182732	ENSMUSG00000021219
UniProt	P49758	Q9Z2H2
RefSeq (mRNA)	NM_001204416	NM_001282061
RefSeq (protein)	NP_001191345	NP_001268990
Location (UCSC)	Chr 14: 71.93 – 72.57 Mb	Chr 12: 82.62 – 83.16 Mb
PubMed search

Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.^[1][2][3]

Members of the RGS (regulator of G protein signaling) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits.[supplied by OMIM]^[3]

Interactions

RGS6 has been shown to interact with STMN2^[4] and DMAP1.^[2]

References

1. Seki N, Hattori A, Hayashi A, Kozuma S, Hori T, Saito T (April 1999). "The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3". J Hum Genet 44 (2): 138–40. doi:10.1007/s100380050129. PMID 10083744.
2. Liu Z, Fisher RA (March 2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity". J Biol Chem 279 (14): 14120–8. doi:10.1074/jbc.M309547200. PMID 14734556.
3. "Entrez Gene: RGS6 regulator of G-protein signalling 6".
4. Liu, Zhengyu; Chatterjee Tapan K; Fisher Rory A (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". J. Biol. Chem. (United States) 277 (40): 37832–9. doi:10.1074/jbc.M205908200. ISSN 0021-9258. PMID 12140291.

Further reading

• Sherrington R, Rogaev EI, Liang Y, et al. (1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature 375 (6534): 754–60. doi:10.1038/375754a0. PMID 7596406.
• Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
• Posner BA, Gilman AG, Harris BA (1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509.
• Liu Z, Chatterjee TK, Fisher RA (2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". J. Biol. Chem. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chatterjee TK, Fisher RA (2003). "Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins". J. Biol. Chem. 278 (32): 30272–82. doi:10.1074/jbc.M212688200. PMID 12761220.
• Chatterjee TK, Liu Z, Fisher RA (2003). "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants". J. Biol. Chem. 278 (32): 30261–71. doi:10.1074/jbc.M212687200. PMID 12761221.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.