SUDS3

Suppressor of defective silencing 3 homolog (S. cerevisiae)
Identifiers
Symbols	SUDS3 ; SAP45; SDS3
External IDs	OMIM: 608250 MGI: 1919204 HomoloGene: 15906 GeneCards: SUDS3 Gene
Gene ontology Molecular function • histone deacetylase activity • protein binding • enzyme binding • histone deacetylase binding Cellular component • nucleus • nucleoplasm • cytoplasm • Sin3 complex • Sin3-type complex Biological process • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • transcription, DNA-templated • apoptotic process • gene expression • histone deacetylation • substantia nigra development • regulation of gene expression, epigenetic • positive regulation of apoptotic process • negative regulation of gene expression, epigenetic • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64426	71954
Ensembl	ENSG00000111707	ENSMUSG00000066900
UniProt	Q9H7L9	Q8BR65
RefSeq (mRNA)	NM_022491	NM_001122666
RefSeq (protein)	NP_071936	NP_001116138
Location (UCSC)	Chr 12: 118.38 – 118.42 Mb	Chr 5: 117.09 – 117.12 Mb
PubMed search

Sin3 histone deacetylase corepressor complex component SDS3 is an enzyme that in humans is encoded by the SUDS3 gene.^[1][2]

SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM]^[2]

Interactions

SUDS3 has been shown to interact with HDAC1,^[1][3] Host cell factor C1,^[4] SIN3B^[1] and SIN3A.^[1][3]

References

1. Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H Jr, Chen K, DePinho RA (Mar 2002). "Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex". Mol Cell Biol 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966.
2. "Entrez Gene: SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)".
3. Fleischer, Tracey C; Yun Ui Jeong; Ayer Donald E (May 2003). "Identification and Characterization of Three New Components of the mSin3A Corepressor Complex". Mol. Cell. Biol. (United States) 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. ISSN 0270-7306. PMC 164750. PMID 12724404.
4. Wysocka, Joanna; Myers Michael P; Laherty Carol D; Eisenman Robert N; Herr Winship (Apr 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes Dev. (United States) 17 (7): 896–911. doi:10.1101/gad.252103. ISSN 0890-9369. PMC 196026. PMID 12670868.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Fleischer TC, Yun UJ, Ayer DE (2003). "Identification and Characterization of Three New Components of the mSin3A Corepressor Complex". Mol. Cell. Biol. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
• Wysocka J, Myers MP, Laherty CD, et al. (2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes Dev. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.