SIN3B

SIN3 transcription regulator family member B
PDB rendering based on 1e91.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1e91​, 1pd7​, 2cr7​, 2czy​, 2f05​
Identifiers
Symbols	SIN3B ; KIAA0700
External IDs	OMIM: 607777 MGI: 107158 HomoloGene: 81810 GeneCards: SIN3B Gene
Gene ontology Molecular function • RNA polymerase II transcription corepressor activity • chromatin binding • histone deacetylase activity • protein binding Cellular component • chromatin • X chromosome • Y chromosome • XY body • nucleus • nucleoplasm • cytoplasm • Sin3 complex • autosome Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • skeletal muscle tissue development • histone deacetylation • cellular lipid metabolic process • small molecule metabolic process • cardiac muscle tissue development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23309	20467
Ensembl	ENSG00000127511	ENSMUSG00000031622
UniProt	O75182	Q62141
RefSeq (mRNA)	NM_001297595	NM_001113248
RefSeq (protein)	NP_001284524	NP_001106719
Location (UCSC)	Chr 19: 16.83 – 16.88 Mb	Chr 8: 72.72 – 72.76 Mb
PubMed search

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.^[1][2]

Interactions

SIN3B has been shown to interact with HDAC1,^[3][4] Zinc finger and BTB domain-containing protein 16,^[5] SUDS3^[6] and IKZF1.^[4][7]

See also

• Transcription coregulator

References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
2. "Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)".
3. Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & Development 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591.
4. Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC 1171390. PMID 10357820.
5. David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120.
6. Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (Apr 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966.
7. Koipally J, Georgopoulos K (Aug 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.

Further reading

• Ayer DE, Lawrence QA, Eisenman RN (Mar 1995). "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3". Cell 80 (5): 767–76. doi:10.1016/0092-8674(95)90355-0. PMID 7889570.
• David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120.
• Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC 1171390. PMID 10357820.
• Naruse Y, Aoki T, Kojima T, Mori N (Nov 1999). "Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes". Proceedings of the National Academy of Sciences of the United States of America 96 (24): 13691–6. doi:10.1073/pnas.96.24.13691. PMC 24126. PMID 10570134.
• Spronk CA, Tessari M, Kaan AM, Jansen JF, Vermeulen M, Stunnenberg HG, Vuister GW (Dec 2000). "The Mad1-Sin3B interaction involves a novel helical fold". Nature Structural Biology 7 (12): 1100–4. doi:10.1038/81944. PMID 11101889.
• Spronk CA, Jansen JF, Tessari M, Kaan AM, Aelen J, Lasonder E, Stunnenberg HG, Vuister GW (Apr 2001). "Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1". Journal of Biomolecular NMR 19 (4): 377–8. doi:10.1023/A:1011262214741. PMID 11370785.
• Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (Apr 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966.
• Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD (Apr 2002). "E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex". Genes & Development 16 (8): 933–47. doi:10.1101/gad.969202. PMC 152357. PMID 11959842.
• Koipally J, Georgopoulos K (Aug 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.
• Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA (Feb 2003). "An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B". The Biochemical Journal 369 (Pt 3): 651–7. doi:10.1042/BJ20020854. PMC 1223118. PMID 12398767.
• Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A (May 2003). "The histone deacetylase 9 gene encodes multiple protein isoforms". The Journal of Biological Chemistry 278 (18): 16059–72. doi:10.1074/jbc.M212935200. PMID 12590135.
• Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (Apr 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.
• Dugast-Darzacq C, Pirity M, Blanck JK, Scherl A, Schreiber-Agus N (Nov 2004). "Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential". Oncogene 23 (55): 8887–99. doi:10.1038/sj.onc.1208107. PMID 15467743.
• Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S (Oct 2005). "Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex". Molecular and Cellular Biology 25 (19): 8415–29. doi:10.1128/MCB.25.19.8415-8429.2005. PMC 1265755. PMID 16166625.
• Xu Y, Sengupta PK, Seto E, Smith BD (Apr 2006). "Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression". The Journal of Biological Chemistry 281 (14): 9260–70. doi:10.1074/jbc.M511724200. PMC 1434794. PMID 16464847.

External links

• SIN3B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.