CRTC3

CREB regulated transcription coactivator 3
Identifiers
Symbols CRTC3 ; TORC-3; TORC3
External IDs OMIM: 608986 MGI: 1917711 HomoloGene: 11248 GeneCards: CRTC3 Gene
Orthologs
Species Human Mouse
Entrez 64784 70461
Ensembl ENSG00000140577 ENSMUSG00000030527
UniProt Q6UUV7 Q91X84
RefSeq (mRNA) NM_001042574 NM_173863
RefSeq (protein) NP_001036039 NP_776288
Location (UCSC) Chr 15:
90.53 – 90.65 Mb		 Chr 7:
80.59 – 80.69 Mb
PubMed search

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene.[1][2][3]

This gene has been shown to be linked to weight gain.[4]

References

  1. ↑ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
  2. ↑ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
  3. ↑ "Entrez Gene: CRTC3 CREB regulated transcription coactivator 3".
  4. ↑ Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, Cui J, Jones MR, Chen YD, Taylor KD, Hsueh WA, Rotter JI, Montminy M (Dec 2010). "CRTC3 links catecholamine signalling to energy balance". Nature 468 (7326): 933–939. doi:10.1038/nature09564. PMID 21164481.

Further reading

  • Hishiki T, Ohshima T, Ego T, Shimotohno K (Sep 2007). "BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3". The Journal of Biological Chemistry 282 (39): 28335–43. doi:10.1074/jbc.M702656200. PMID 17644518. 
  • Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC (Sep 2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells". Proceedings of the National Academy of Sciences of the United States of America 103 (39): 14379–84. doi:10.1073/pnas.0606714103. PMC 1569674. PMID 16980408. 
  • Koga H, Ohshima T, Shimotohno K (Dec 2004). "Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3". The Journal of Biological Chemistry 279 (51): 52978–83. doi:10.1074/jbc.M409021200. PMID 15466468.  Check date values in: |year= / |date= mismatch (help)
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 

External links


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