BCAS3

Breast carcinoma amplified sequence 3
Identifiers
Symbols	BCAS3 ; GAOB1; MAAB
External IDs	OMIM: 607470 MGI: 2385848 HomoloGene: 9778 GeneCards: BCAS3 Gene
Gene ontology Molecular function • chromatin binding • protein binding • transcription factor binding • acetyltransferase activator activity • histone acetyltransferase binding • nuclear hormone receptor binding • histone binding • beta-tubulin binding Cellular component • nucleus • cytoplasm • cytoplasmic microtubule • cell leading edge • transcriptionally active chromatin • intermediate filament cytoskeleton • cell periphery Biological process • angiogenesis • transcription, DNA-templated • Golgi organization • positive regulation of endothelial cell migration • microtubule organizing center organization • negative regulation of GTPase activity • tube formation • response to starvation • positive regulation of catalytic activity • positive regulation of GTPase activity • positive regulation of transcription from RNA polymerase II promoter • positive regulation of filopodium assembly • negative regulation of focal adhesion assembly • cellular response to estrogen stimulus • positive regulation of intracellular protein transport • activation of GTPase activity • regulation of establishment of cell polarity • positive regulation of actin cytoskeleton reorganization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54828	192197
Ensembl	ENSG00000141376	ENSMUSG00000059439
UniProt	Q9H6U6	Q8CCN5
RefSeq (mRNA)	NM_001099432	NM_001166642
RefSeq (protein)	NP_001092902	NP_001160114
Location (UCSC)	Chr 17: 60.68 – 61.39 Mb	Chr 11: 85.35 – 85.83 Mb
PubMed search

Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene.^[1][2] BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.^[2]

Function

The BCAS3 gene is regulated by estrogen receptor alpha (ER-α).^[3] The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α.^[4] Furthermore BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in a positive feedback loop leading to ER-α mediated signal amplification.^[4]

References

1. "Entrez Gene: BCAS3 breast carcinoma amplified sequence 3".
2. Bärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A (December 2002). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer 35 (4): 311–7. doi:10.1002/gcc.10121. PMID 12378525.
3. Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R (April 2006). "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. doi:10.1073/pnas.0601989103. PMC 1458939. PMID 16617102.
4. Gururaj AE, Peng S, Vadlamudi RK, Kumar R (August 2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. doi:10.1210/me.2006-0514. PMID 17505058.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bärlund M, Monni O, Weaver JD; et al. (2003). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer 35 (4): 311–7. doi:10.1002/gcc.10121. PMID 12378525.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gururaj AE, Singh RR, Rayala SK; et al. (2006). "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. doi:10.1073/pnas.0601989103. PMC 1458939. PMID 16617102.
• Gururaj AE, Holm C, Landberg G, Kumar R (2006). "Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer". Cell Cycle 5 (13): 1407–10. doi:10.4161/cc.5.13.2924. PMID 16855396.
• Gururaj AE, Peng S, Vadlamudi RK, Kumar R (2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. doi:10.1210/me.2006-0514. PMID 17505058.