LCOR

Ligand dependent nuclear receptor corepressor
PDB rendering based on 2cob.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2COB​
Identifiers
Symbols	LCOR ; MLR2
External IDs	OMIM: 607698 MGI: 2443930 HomoloGene: 18153 GeneCards: LCOR Gene
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • transcription factor binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84458	212391
Ensembl	ENSG00000196233	ENSMUSG00000025019
UniProt	Q96JN0	Q6ZPI3
RefSeq (mRNA)	NM_001170765	NM_172154
RefSeq (protein)	NP_001164236	NP_742166
Location (UCSC)	Chr 10: 96.83 – 96.98 Mb	Chr 19: 41.48 – 41.56 Mb
PubMed search

Ligand-dependent corepressor is a protein that in humans is encoded by the LCOR gene.^[1][2][3]

Function

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.^[3]

References

1. Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VK, Yang XJ, White JH (Jan 2003). "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms". Mol Cell 11 (1): 139–50. doi:10.1016/S1097-2765(03)00014-5. PMID 12535528.
2. White JH, Fernandes I, Mader S, Yang XJ (Jun 2004). "Corepressor recruitment by agonist-bound nuclear receptors". Vitam Horm 68: 123–43. doi:10.1016/S0083-6729(04)68004-6. PMID 15193453.
3. "Entrez Gene: LCOR ligand dependent nuclear receptor corepressor".

Further reading

• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kunieda T, Park JM, Takeuchi H, Kubo T (2003). "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1).". FEBS Lett. 535 (1–3): 61–5. doi:10.1016/S0014-5793(02)03858-9. PMID 12560079.
• Shi Y, Sawada J, Sui G, et al. (2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature 422 (6933): 735–8. doi:10.1038/nature01550. PMID 12700765.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.