NCOA5

Nuclear receptor coactivator 5
PDB rendering based on 1v95.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1V95​, 2J7X​, 2J7Y​
Identifiers
Symbols	NCOA5 ; CIA; bA465L10.6
External IDs	MGI: 2385165 HomoloGene: 32496 GeneCards: NCOA5 Gene
Gene ontology Molecular function • chromatin binding • protein binding • poly(A) RNA binding Cellular component • extracellular space • nucleus • nucleoplasm • actin cytoskeleton Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • glucose homeostasis • negative regulation of insulin receptor signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57727	228869
Ensembl	ENSG00000124160	ENSMUSG00000039804
UniProt	Q9HCD5	Q91W39
RefSeq (mRNA)	NM_020967	NM_144892
RefSeq (protein)	NP_066018	NP_659141
Location (UCSC)	Chr 20: 46.06 – 46.09 Mb	Chr 2: 165 – 165.03 Mb
PubMed search

Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5 gene.^[1][2]

Function

This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor Rev-ErbA beta. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined.^[1]

References

1. "Entrez Gene: NCOA5 nuclear receptor coactivator 5".
2. Sauvé F, McBroom LD, Gallant J, Moraitis AN, Labrie F, Giguère V (January 2001). "CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant". Molecular and Cellular Biology 21 (1): 343–53. doi:10.1128/MCB.21.1.343-353.2001. PMC 88807. PMID 11113208.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Jiang C, Ito M, Piening V, et al. (2004). "TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription". J. Biol. Chem. 279 (26): 27781–9. doi:10.1074/jbc.M401809200. PMID 15073177.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Sauvé F, McBroom LD, Gallant J, et al. (2001). "CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant". Mol. Cell. Biol. 21 (1): 343–53. doi:10.1128/MCB.21.1.343-353.2001. PMC 88807. PMID 11113208.
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.

External links

• NCOA5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C93

This article incorporates text from the United States National Library of Medicine, which is in the public domain.