CARM1

coactivator-associated arginine methyltransferase 1
Crystal Structure of Coactivator Associated Arginine Methyltransferase 1[1]
Identifiers
Symbol	CARM1
Entrez	10498
HUGO	23393
OMIM	603934
RefSeq	XM_032719
UniProt	Q86X55
Other data
EC number	2.1.1.125
Locus	Chr. 19 p13.2

coactivator associated arginine methyltransferase 1-like
Identifiers
Symbol	CARM1L
Entrez	256280
HUGO	23392
RefSeq	XM_171224
UniProt	Q5SZY8
Other data
Locus	Chr. 9 p24.2

CARM1 (coactivator-associated arginine methyltransferase 1), also known as PRMT4 (protein arginine N-methyltransferase 4), is an enzyme (EC 2.1.1.125) encoded by the CARM1 gene found in human beings, as well as many other mammals.^[2] It has a polypeptide (L) chain type that is 348 residues long, and is made up of alpha helices and beta sheets.^[3] Its main function includes catalyzing the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.^[4] CARM1 is a secondary coactivator through its association with p160 family (SRC-1, GRIP1, AIB) of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts.^[5] This gene also plays an important role in androgen receptors and may play a role in prostate cancer progression.^[6][7]

See also

• histone-arginine N-methyltransferase

External links

• coactivator-associated arginine methyltransferase 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C30

References

1. "RCSB Protein Data Bank - Structure Summary for 2Y1W - CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR".
2. Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, Aswad DW, Stallcup MR (1999). "Regulation of transcription by a protein methyltransferase". Science 284 (5423): 2174–7. doi:10.1126/science.284.5423.2174. PMID 10381882.
3. "RCSB Protein Data Bank - Sequence / Structure Details for 2Y1W - CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR".
4. "CARM1 Gene - GeneCards | CARM1 Protein | CARM1 Antibody".
5. Torres-Padilla ME, Parfitt DE, Kouzarides T, Zernicka-Goetz M (2007). "Histone arginine methylation regulates pluripotency in the early mouse embryo". Nature 445 (7124): 214–8. doi:10.1038/nature05458. PMC 3353120. PMID 17215844.
6. Hong H, Kao C, Jeng MH, Eble JN, Koch MO, Gardner TA, Zhang S, Li L, Pan CX, Hu Z, MacLennan GT, Cheng L (2004). "Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status". Cancer 101 (1): 83–9. doi:10.1002/cncr.20327. PMID 15221992.
7. Majumder S, Liu Y, Ford OH, Mohler JL, Whang YE (2006). "Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability". Prostate 66 (12): 1292–301. doi:10.1002/pros.20438. PMID 16705743.