TRIM33

Tripartite motif containing 33
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3U5M​, 3U5N​, 3U5O​, 3U5P​
Identifiers
Symbols	TRIM33 ; ECTO; PTC7; RFG7; TF1G; TIF1G; TIF1GAMMA; TIFGAMMA
External IDs	OMIM: 605769 MGI: 2137357 HomoloGene: 9296 GeneCards: TRIM33 Gene
Gene ontology Molecular function • DNA binding • ubiquitin-protein transferase activity • protein binding • zinc ion binding • ligase activity • co-SMAD binding • R-SMAD binding Cellular component • nucleus • nucleoplasm • intracellular membrane-bounded organelle Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • transforming growth factor beta receptor signaling pathway • gene expression • protein ubiquitination • regulation of transforming growth factor beta receptor signaling pathway • negative regulation of BMP signaling pathway • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51592	94093
Ensembl	ENSG00000197323	ENSMUSG00000033014
UniProt	Q9UPN9	Q99PP7
RefSeq (mRNA)	NM_015906	NM_001079830
RefSeq (protein)	NP_056990	NP_001073299
Location (UCSC)	Chr 1: 114.39 – 114.51 Mb	Chr 3: 103.28 – 103.36 Mb
PubMed search

Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ), is a human gene.^[1][2]

The protein encoded by this gene is thought to be a transcriptional corepressor. However unlike the related TIF1-α and TIF1-β proteins, few transcription factors such as Smad4 that interact with TIF1-γ have been identified.^[1]

Structure

The protein is a member of the tripartite motif family.^[3] This motif includes three zinc-binding domains:

• RING
• B-box type 1 zinc finger
• B-box type 2 zinc finger

and a coiled-coil region.

Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.^[1]

Interactions

TRIM33 has been shown to interact with TRIM24.^[4]

Role in cancer

TRIM33 acts as a tumor suppressor gene preventing the development chronic myelomonocytic leukemia.^[5] TRIM33 regulates also the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells. ^[6] TRIM33 acts as an oncogene by preventing apoptosis in B-cell leukemias.^[7]

References

1. "Entrez Gene: TRIM33 tripartite motif-containing 33".
2. Venturini L, You J, Stadler M, Galien R, Lallemand V, Koken MH, Mattei MG, Ganser A, Chambon P, Losson R, de Thé H; You; Stadler; Galien; Lallemand; Koken; Mattei; Ganser; Chambon; Losson; De Thé (February 1999). "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene 18 (5): 1209–17. doi:10.1038/sj.onc.1202655. PMID 10022127.
3. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A; Meroni; Fantozzi; Merla; Cairo; Luzi; Riganelli; Zanaria; Messali; Cainarca; Guffanti; Minucci; Pelicci; Ballabio (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
4. Peng, Hongzhuang; Feldman Irina; Rauscher Frank J (Jul 2002). "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". J. Mol. Biol. (England) 320 (3): 629–44. doi:10.1016/S0022-2836(02)00477-1. ISSN 0022-2836. PMID 12096914.
5. Aucagne, R; Droin, N; Paggetti, J; Lagrange, B; Largeot, A; Hammann, A; Bataille, A; Martin, L; Yan, K. P.; Fenaux, P; Losson, R; Solary, E; Bastie, J. N.; Delva, L (2011). "Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia". Journal of Clinical Investigation 121 (6): 2361–70. doi:10.1172/JCI45213. PMC 3104753. PMID 21537084.
6. Quéré, R; Saint-Paul, L; Carmignac, V; Martin, R; Chrétien, M; Largeot, A; Hammann, A; Pais de Barros, J. P.; Bastie, J. N.; Delva, L (2014). "Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells". Proc Natl Acad Sci U S A 111 (29): 10592–7. doi:10.1073/pnas.1405546111. PMC 4115559. PMID 25002492.
7. Wang, E; Kawaoka, S; Roe, J. S.; Shi, J; Hohmann, A. F.; Xu, Y; Bhagwat, A. S.; Suzuki, Y; Kinney, J. B.; Vakoc, C. R. (2015). "The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer". eLife 4. doi:10.7554/eLife.06377. PMID 25919951.

Further reading

• Venturini L, You J, Stadler M, et al. (1999). "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene 18 (5): 1209–17. doi:10.1038/sj.onc.1202655. PMID 10022127.
• Klugbauer S, Rabes HM; Rabes (1999). "The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas". Oncogene 18 (30): 4388–93. doi:10.1038/sj.onc.1202824. PMID 10439047.
• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
• Peng H, Feldman I, Rauscher FJ; Feldman; Rauscher Fj (2002). "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". J. Mol. Biol. 320 (3): 629–44. doi:10.1016/S0022-2836(02)00477-1. PMID 12096914.
• Yoon HG, Chan DW, Reynolds AB, et al. (2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Dupont S, Zacchigna L, Cordenonsi M, et al. (2005). "Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase". Cell 121 (1): 87–99. doi:10.1016/j.cell.2005.01.033. PMID 15820681.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• He W, Dorn DC, Erdjument-Bromage H, et al. (2006). "Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway". Cell 125 (5): 929–41. doi:10.1016/j.cell.2006.03.045. PMID 16751102.

External links

• TRIM33 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.