Sarcospan

sarcospan
Identifiers
Symbol	SSPN
Entrez	8082
HUGO	11322
OMIM	601599
Other data
Locus	Chr. 12 p11.2

Sarcospan, discovered by the research group of Kevin Campbell, is a 25-kDa transmembrane protein located in the dystrophin-associated protein complex of skeletal muscle cells. It contains four transmembrane spanning helices with both N- and C-terminal domains located intracellularly.^[1] Loss of sarcospan expression occurs in patients with Duchenne muscular dystrophy, indicating that dystrophin is required for proper localization of sarcospan.^[1] Sarcospan knockout mice exhibit normal muscle structure and function, indicating that sarcospan is not necessary for muscle to develop.^[2]

References

1. Crosbie; Heighway, J; Venzke, DP; Lee, JC; Campbell, KP; et al. (1997). "Sarcospan, the 25-kDa transmembrane component of the dystrophin-glycoprotein complex". J Biol Chem 272 (50): 31221–4. doi:10.1074/jbc.272.50.31221. PMID 9395445.
2. Lebakken; Venzke, DP; Hrstka, RF; Consolino, CM; Faulkner, JA; Williamson, RA; Campbell, KP; et al. (2000). "Sarcospan-deficient mice maintain normal muscle function.". Mol Cell Biol 20 (5): 1669–77. doi:10.1128/MCB.20.5.1669-1677.2000. PMC 85350. PMID 10669744.

External links

• Sarcospan at the US National Library of Medicine Medical Subject Headings (MeSH)