Short-chain acyl-CoA dehydrogenase

Short-chain acyl-CoA dehydrogenase
Identifiers
EC number	1.3.8.1
CAS number	9027-88-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Short-chain acyl-CoA dehydrogenase (EC 1.3.8.1, butyryl-CoA dehydrogenase, butanoyl-CoA dehydrogenase, butyryl dehydrogenase, unsaturated acyl-CoA reductase, ethylene reductase, enoyl-coenzyme A reductase, unsaturated acyl coenzyme A reductase, butyryl coenzyme A dehydrogenase, short-chain acyl CoA dehydrogenase, short-chain acyl-coenzyme A dehydrogenase, 3-hydroxyacyl CoA reductase, butanoyl-CoA:(acceptor) 2,3-oxidoreductase, ACADS (gene).) is an enzyme with systematic name short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase.^{[1][2][3][4][5][6][7]} This enzyme catalyses the following chemical reaction

a short-chain acyl-CoA + electron-transfer flavoprotein $\rightleftharpoons$ a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein

This enzyime contains FAD as prosthetic group.

References

1. Mahler, H.R. (1954). "Studies on the fatty acid oxidizing system of animal tissue. IV. The prosthetic group of butyryl coenzyme A dehydrogenase". J. Biol. Chem. 206 (1): 13–26. PMID 13130522.
2. Green, D.E., Mii, S., Mahler, H.R. and Bock, R.M. (1954). "Studies on the fatty acid oxidizing system of animal tissue. III. Butyryl coenzyme A dehydrogenase". J. Biol. Chem. 206 (1): 1–12. PMID 13130521.
3. Beinert, H. (1963). "Acyl coenzyme A dehydrogenase". In Boyer, P.D., Lardy, H. and Myrbäck, K. The Enzymes 7 (2nd ed.). New York: Academic Press. pp. 447–466.
4. Shaw, L. and Engel, P.C. (1984). "The purification and properties of ox liver short-chain acyl-CoA dehydrogenase". Biochem. J. 218 (2): 511–520. PMC 1153367. PMID 6712627.
5. Thorpe, C. and Kim, J.J. (1995). "Structure and mechanism of action of the acyl-CoA dehydrogenases". FASEB J. 9 (9): 718–725. PMID 7601336.
6. Ikeda, Y., Ikeda, K.O. and Tanaka, K. (1985). "Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme". J. Biol. Chem. 260 (2): 1311–1325. PMID 3968063.
7. McMahon, B., Gallagher, M.E. and Mayhew, S.G. (2005). "The protein coded by the PP2216 gene of Pseudomonas putida KT2440 is an acyl-CoA dehydrogenase that oxidises only short-chain aliphatic substrates". FEMS Microbiol. Lett. 250 (1): 121–127. doi:10.1016/j.femsle.2005.06.049. PMID 16024185.

External links

• Short-chain acyl-CoA dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)