Sorbitol-6-phosphate 2-dehydrogenase

sorbitol-6-phosphate 2-dehydrogenase
Identifiers
EC number 1.1.1.140
CAS number 37250-69-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a sorbitol-6-phosphate dehydrogenase (EC 1.1.1.140) is an enzyme that catalyzes the chemical reaction

D-sorbitol 6-phosphate + NAD+ \rightleftharpoons D-fructose 6-phosphate + NADH + H+

Thus, the two substrates of this enzyme are D-sorbitol 6-phosphate and NAD+, whereas its 3 products are D-fructose 6-phosphate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase. Other names in common use include ketosephosphate reductase, ketosephosphate reductase, D-sorbitol 6-phosphate dehydrogenase, D-sorbitol-6-phosphate dehydrogenase, sorbitol-6-P-dehydrogenase, and D-glucitol-6-phosphate dehydrogenase. This enzyme participates in fructose and mannose metabolism.

References


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