Stephen D. M. Brown

For other people called Steve Brown, see Steve Brown.
Steve Brown

Steve Brown in 2015, portrait from the Royal Society
Born Stephen David Macleod Brown
(1955-05-03) 3 May 1955[1]
Dumfries, Scotland[1]
Fields
Institutions
Alma mater University of Cambridge (BA, PhD)
Thesis The molecular organisation and evolution of rodent genomes (1981)
Doctoral advisor Gabriel Dover[5][6][7]
Doctoral students
  • Mahmood Bhutta[8]
  • Leanne Carrott[9]
  • Michael Crompton[10] 
Notable awards
Website
www.har.mrc.ac.uk/research/lifetime-studies/genetics-and-pathobiology-deafness

Steve David Macleod Brown FRS[11] FMedSci[2] is director of the Medical Research Council (MRC) Mammalian Genetics Unit, MRC Harwell at Harwell Science and Innovation Campus, Oxfordshire,[11][12][13][14][15] a research centre on mouse genetics. In addition, he is the head of the Genetics and Pathobiology of Deafness research group there.[16]

Education

Brown was educated at Belfast Royal Academy[1] and St Catharine's College, Cambridge where he was awarded a Bachelor of Arts degree in 1977[1] followed by a PhD in 1981 for research on the molecular organisation and evolution of rodent genomes[17] supervised by Gabriel Dover.[5]

Research

Brown conducts research in mouse genetics and genomics. He has studied repeated sequences in the DNA of mice and produced molecular maps of mouse chromosomes, which were used to sequence the mouse genome.[5][11][18] He subsequently pioneered efforts to functionally annotate the mouse genome and identify and generate novel disease models through mutagenesis and phenotyping. In particular, he has identified key proteins involved in hearing, contributing to the understanding of the genetics of deafness.[11] For example, research in Brown's laboratory has shown that a mutation in the Evi1 gene increases susceptibility to inflammation of the middle ear (otitis media) in mice, leading to hearing loss.[19]

A particular focus has been the use of mouse models to elucidate the molecular basis of genetic deafness. With Karen Steel, he discovered myosin VIIA as the gene underlying the shaker-1 mutant — one of the first deafness genes to be identified.[20]

Career

Prior to being appointed director of Harwell in 1998, Brown was a professor at Imperial College London.[21] He is chair of the International Mouse Phenotyping Consortium steering committee and joint editor-in-chief of the journal Mammalian Genome.[22][23]

Awards and honours

Brown was awarded The Genetics Society Medal in 2009, elected a Fellow of the Academy of Medical Sciences in 2001.,[2] and elected a Fellow of the Royal Society (FRS) in 2015.[11][20] His certificate of election reads:

“ Stephen Brown is distinguished for his research in mouse genetics and genomics. He pioneered studies of repeated sequences in the mouse genome and the use of novel approaches to generate molecular maps of mouse chromosomes, work that underpinned the sequencing of the mouse genome. He has been at the forefront of new approaches in mutagenesis and phenotyping for the functional annotation of the mouse genome and the identification and characterisation of disease models. Notably, in collaboration he has utilised the mouse to study the genetics of deafness, identifying key proteins involved in auditory transduction, which has transformed our understanding in this field.[11] ”

References

  1. 1 2 3 4 BROWN, Stephen David Macleod. Who's Who 2016 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
  2. 1 2 3 4 "Professor Steve Brown FRS FMedSci". London: Academy of Medical Sciences. Archived from the original on 2015-06-04.
  3. ↑ Brown, S. D.; Hancock, J. M.; Gates, H (2006). "Understanding mammalian genetic systems: The challenge of phenotyping in the mouse". PLoS Genetics 2 (8): e118. doi:10.1371/journal.pgen.0020118. PMC 1557775. PMID 16933996.
  4. ↑ Steel, Karen P.; Brown, Stephen D.M. (1994). "Genes and deafness". Trends in Genetics 10 (12): 428–35. doi:10.1016/0168-9525(94)90113-9. PMID 7871592.
  5. 1 2 3 Brown, S. D. M.; Dover, G. A. (1980). "Conservation of segmental variants of satellite DNA of Mus musculus in a related species: Mus spretus". Nature 285 (5759): 47–49. doi:10.1038/285047a0. ISSN 0028-0836.
  6. ↑ Dover, G. A.; Strachan, T; Coen, E. S.; Brown, S. D. (1982). "Molecular drive". Science 218 (4577): 1069. doi:10.1126/science.7146895. PMID 7146894.
  7. ↑ Brown, S. D.; Dover, G (1981). "Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes". Journal of Molecular Biology 150 (4): 441–66. doi:10.1016/0022-2836(81)90374-0. PMID 6276556.
  8. ↑ Bhutta, Mahmood F. (2012). Genetics of chronic otitis media : a mouse to man approach (PhD thesis). University of Oxford.
  9. ↑ Carrott, Leanne J. (2014). Characterisation of pitch : an early onset model of sensorineural deafness (PhD thesis). University of Oxford.
  10. ↑ Crompton, Michael (2014). 'edison' : a novel model of otitis media (DPhil thesis). University of Oxford.
  11. 1 2 3 4 5 6 7 "Professor Stephen Brown FMedSci FRS". London: The Royal Society. Archived from the original on 2015-05-02.
  12. ↑ Silver, L. M.; Nadeau, J. H.; Brown, S. D. M.; Eppig, J. T.; Peters, J (1998). "Mammalian Genome, Incorporating Mouse Genome". Mammalian genome : official journal of the International Mammalian Genome Society 9 (1): 1. doi:10.1007/s003359900669. PMID 9435276.
  13. ↑ Brown, S. D.; Moore, M. W. (2012). "The International Mouse Phenotyping Consortium: Past and future perspectives on mouse phenotyping". Mammalian Genome 23 (9-10): 632–40. doi:10.1007/s00335-012-9427-x. PMC 3774932. PMID 22940749.
  14. ↑ Brown, S. D. M.; Moore, M. W. (2012). "Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium". Disease Models & Mechanisms 5 (3): 289–292. doi:10.1242/dmm.009878. ISSN 1754-8403.
  15. ↑ "Profile: Steve Brown". Medical Research Council. Archived from the original on 2015-06-04.
  16. ↑ "Genetics and Pathobiology of Deafness research group". Harwell: MRC Harwell.
  17. ↑ Brown, Stephen D. M. (1981). The molecular organisation and evolution of rodent genomes (PhD thesis). University of Cambridge. OCLC 556404448.
  18. ↑ Brown, S. D.; Dover, G (1981). "Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes". Journal of Molecular Biology 150 (4): 441–66. doi:10.1016/0022-2836(81)90374-0. PMID 6276556.
  19. ↑ Parkinson, N; Hardisty-Hughes, R. E.; Tateossian, H; Tsai, H. T.; Brooker, D; Morse, S; Lalane, Z; MacKenzie, F; Fray, M; Glenister, P; Woodward, A. M.; Polley, S; Barbaric, I; Dear, N; Hough, T. A.; Hunter, A. J.; Cheeseman, M. T.; Brown, S. D. (2006). "Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media". PLoS Genetics 2 (10): e149. doi:10.1371/journal.pgen.0020149. PMC 1592239. PMID 17029558.
  20. 1 2 "Professor Steve Brown FMedSci FRS". London: Royal Society. Archived from the original on 2015-11-17. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived September 25, 2015)
  21. ↑ "MRC Harwell Timeline". Medical Research Council. Archived from the original on 2014-09-24.
  22. ↑ "Mammalian Genome: Editorial Board". Springer. Retrieved 14 August 2015.
  23. ↑ "IMPC Steering Committee". International Mouse Phenotyping Consortium.
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