TAF4B

TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
Identifiers
Symbols	TAF4B ; SPGF13; TAF2C2; TAFII105
External IDs	OMIM: 601689 MGI: 2152345 HomoloGene: 28266 GeneCards: TAF4B Gene
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • protein heterodimerization activity • NF-kappaB binding Cellular component • nucleoplasm • transcription factor TFIID complex • nucleolus • cytoplasm Biological process • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • spermatogenesis • gene expression • viral process • oogenesis • positive regulation of stem cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6875	72504
Ensembl	ENSG00000141384	ENSMUSG00000054321
UniProt	Q92750	G5E8Z2
RefSeq (mRNA)	NM_001293725	NM_001100449
RefSeq (protein)	NP_001280654	NP_001093919
Location (UCSC)	Chr 18: 26.23 – 26.39 Mb	Chr 18: 14.78 – 14.9 Mb
PubMed search

Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene.^[1][2][3]

Function

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM]^[3]

Interactions

TAF4B has been shown to interact with RELA.^[4]

References

1. Dikstein R, Zhou S, Tjian R (Nov 1996). "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130". Cell 87 (1): 137–46. doi:10.1016/S0092-8674(00)81330-6. PMID 8858156.
2. Yamit-Hezi A, Nir S, Wolstein O, Dikstein R (Jul 2000). "Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes". J. Biol. Chem. 275 (24): 18180–7. doi:10.1074/jbc.275.24.18180. PMID 10849440.
3. "Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa".
4. Yamit-Hezi A, Dikstein R (Sep 1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC 1170844. PMID 9724652.

Further reading

• Liu WL, Coleman RA, Grob P, King DS, Florens L, Washburn MP, Geles KG, Yang JL, Ramey V, Nogales E, Tjian R (2008). "Structural changes in TAF4b-TFIID correlate with promoter selectivity". Mol. Cell 29 (1): 81–91. doi:10.1016/j.molcel.2007.11.003. PMC 2486835. PMID 18206971.
• Wu Y, Lu Y, Hu Y, Li R (2005). "Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line". J. Cell. Biochem. 96 (4): 751–9. doi:10.1002/jcb.20577. PMID 16088961.
• Shao H, Revach M, Moshonov S, Tzuman Y, Gazit K, Albeck S, Unger T, Dikstein R (2005). "Core promoter binding by histone-like TAF complexes". Mol. Cell. Biol. 25 (1): 206–19. doi:10.1128/MCB.25.1.206-219.2005. PMC 538770. PMID 15601843.
• Rashevsky-Finkel A, Silkov A, Dikstein R (2001). "A composite nuclear export signal in the TBP-associated factor TAFII105". J. Biol. Chem. 276 (48): 44963–9. doi:10.1074/jbc.M106112200. PMID 11567023.
• Wolstein O, Silkov A, Revach M, Dikstein R (2000). "Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription". J. Biol. Chem. 275 (22): 16459–65. doi:10.1074/jbc.275.22.16459. PMID 10828057.
• Yamit-Hezi A, Dikstein R (1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC 1170844. PMID 9724652.