TLK2

Tousled-like kinase 2
Identifiers
Symbols	TLK2 ; HsHPK; PKU-ALPHA
External IDs	OMIM: 608439 MGI: 1346023 HomoloGene: 4993 ChEMBL: 5404 GeneCards: TLK2 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • protein binding • ATP binding Cellular component • nucleus • intermediate filament • perinuclear region of cytoplasm Biological process • regulation of chromatin assembly or disassembly • protein phosphorylation • cellular response to DNA damage stimulus • cell cycle • chromosome segregation • negative regulation of autophagy • chromatin modification • peptidyl-serine phosphorylation • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • intracellular signal transduction • cellular response to gamma radiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11011	24086
Ensembl	ENSG00000146872	ENSMUSG00000020694
UniProt	Q86UE8	O55047
RefSeq (mRNA)	NM_001112707	NM_001112705
RefSeq (protein)	NP_001271262	NP_001106176
Location (UCSC)	Chr 17: 62.46 – 62.62 Mb	Chr 11: 105.18 – 105.28 Mb
PubMed search

Serine/threonine-protein kinase tousled-like 2 is an enzyme that in humans is encoded by the TLK2 gene.^[1][2][3]

Function

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]^[3]

Interactions

TLK2 has been shown to interact with TLK1,^[2] ASF1B^[4][5] and ASF1A.^[5]

References

1. Yamakawa A, Kameoka Y, Hashimoto K, Yoshitake Y, Nishikawa K, Tanihara K, Date T (Nov 1997). "cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal". Gene 202 (1-2): 193–201. doi:10.1016/S0378-1119(97)00495-2. PMID 9427565.
2. Silljé HH, Takahashi K, Tanaka K, Van Houwe G, Nigg EA (Oct 1999). "Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication". The EMBO Journal 18 (20): 5691–702. doi:10.1093/emboj/18.20.5691. PMC 1171636. PMID 10523312.
3. "Entrez Gene: TLK2 tousled-like kinase 2".
4. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
5. Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology 11 (13): 1068–73. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414.

Further reading

• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Zhang S, Xing H, Muslin AJ (Aug 1999). "Nuclear localization of protein kinase U-alpha is regulated by 14-3-3". The Journal of Biological Chemistry 274 (35): 24865–72. doi:10.1074/jbc.274.35.24865. PMID 10455159.
• Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology 11 (13): 1068–73. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414.
• Groth A, Lukas J, Nigg EA, Silljé HH, Wernstedt C, Bartek J, Hansen K (Apr 2003). "Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint". The EMBO Journal 22 (7): 1676–87. doi:10.1093/emboj/cdg151. PMC 152895. PMID 12660173.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.