ASF1B
| Anti-silencing function 1B histone chaperone | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ASF1B ; CIA-II | ||||||||||||
| External IDs | OMIM: 609190 MGI: 1914179 HomoloGene: 56797 GeneCards: ASF1B Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 55723 | 66929 | |||||||||||
| Ensembl | ENSG00000105011 | ENSMUSG00000005470 | |||||||||||
| UniProt | Q9NVP2 | Q9DAP7 | |||||||||||
| RefSeq (mRNA) | NM_018154 | NM_024184 | |||||||||||
| RefSeq (protein) | NP_060624 | NP_077146 | |||||||||||
| Location (UCSC) |
Chr 19: 14.12 – 14.14 Mb |
Chr 8: 83.96 – 83.97 Mb | |||||||||||
| PubMed search | |||||||||||||
Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene.[1][2][3]
Function
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.[3]
Interactions
ASF1B has been shown to interact with TLK2,[2][4] CHAF1B,[1][4] TLK1[2][4] and CHAF1A.[1][4]
References
- 1 2 3 Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056. PMID 11897662.
- 1 2 3 Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology 11 (13): 1068–73. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414.
- 1 2 "Entrez Gene: ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae)".
- 1 2 3 4 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Further reading
- Loyola A, Almouzni G (Mar 2004). "Histone chaperones, a supporting role in the limelight". Biochimica et Biophysica Acta 1677 (1-3): 3–11. doi:10.1016/j.bbaexp.2003.09.012. PMID 15020040.
- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Umehara T, Horikoshi M (Sep 2003). "Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis". The Journal of Biological Chemistry 278 (37): 35660–7. doi:10.1074/jbc.M303549200. PMID 12842904.
- Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Groth A, Ray-Gallet D, Quivy JP, Lukas J, Bartek J, Almouzni G (Jan 2005). "Human Asf1 regulates the flow of S phase histones during replicational stress". Molecular Cell 17 (2): 301–11. doi:10.1016/j.molcel.2004.12.018. PMID 15664198.
- Sen SP, De Benedetti A (2006). "TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1". BMC Molecular Biology 7: 37. doi:10.1186/1471-2199-7-37. PMC 1626478. PMID 17054786.
- Hayashi R, Goto Y, Tanaka R, Oonogi K, Hisasue M, Yoshida K (Feb 2007). "Transcriptional regulation of human chromatin assembly factor ASF1". DNA and Cell Biology 26 (2): 91–9. doi:10.1089/dna.2006.0515. PMID 17328667.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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