TRNA (guanine37-N1)-methyltransferase

TRNA (guanine³⁷-N¹)-methyltransferase (EC 2.1.1.228, TrmD, tRNA (m1G37) methyltransferase, transfer RNA (m1G37) methyltransferase, Trm5p, TRMT5, tRNA-(N1G37) methyltransferase, MJ0883 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine³⁷-N¹)-methyltransferase.^[1]^[2]^[3]^[4]^[5]^[6] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine³⁷ in tRNA

\rightleftharpoons

S-adenosyl-L-homocysteine + N¹-methylguanine³⁷ in tRNA

This enzyme is important for the maintenance of the correct reading frame during translation.

References

↑ Takeda, H., Toyooka, T., Ikeuchi, Y., Yokobori, S., Okadome, K., Takano, F., Oshima, T., Suzuki, T., Endo, Y. and Hori, H. (2006). "The substrate specificity of tRNA (m¹G³⁷) methyltransferase (TrmD) from Aquifex aeolicus". Genes Cells 11: 1353–1365. doi:10.1111/j.1365-2443.2006.01022.x. PMID 17121543.
↑ Lee, C., Kramer, G., Graham, D.E. and Appling, D.R. (2007). "Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N¹-)-methyltransferase". J. Biol. Chem. 282: 27744–27753. doi:10.1074/jbc.m704572200. PMID 17652090.
↑ O'Dwyer, K., Watts, J.M., Biswas, S., Ambrad, J., Barber, M., Brule, H., Petit, C., Holmes, D.J., Zalacain, M. and Holmes, W.M. (2004). "Characterization of Streptococcus pneumoniae TrmD, a tRNA methyltransferase essential for growth". J. Bacteriol. 186: 2346–2354. doi:10.1128/jb.186.8.2346-2354.2004. PMID 15060037.
↑ Brule, H., Elliott, M., Redlak, M., Zehner, Z.E. and Holmes, W.M. (2004). "Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein". Biochemistry 43: 9243–9255. doi:10.1021/bi049671q. PMID 15248782.
↑ Goto-Ito, S., Ito, T., Ishii, R., Muto, Y., Bessho, Y. and Yokoyama, S. (2008). "Crystal structure of archaeal RNA(m¹G37)methyltransferase aTrm5". Proteins 72: 1274–1289. doi:10.1002/prot.22019. PMID 18384044.
↑ Ahn, H.J., Kim, H.W., Yoon, H.J., Lee, B.I., Suh, S.W. and Yang, J.K. (2003). "Crystal structure of tRNA(m¹G³⁷)methyltransferase: insights into tRNA recognition". EMBO J. 22: 2593–2603. doi:10.1093/emboj/cdg269. PMID 12773376.

External links

TRNA (guanine37-N1)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase

O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase

Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase

Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase

Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase

Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase

Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

2.1.4: Amidine

Arginine:glycine amidinotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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