TRNA dimethylallyltransferase

TRNA dimethylallyltransferase (EC 2.5.1.75, tRNA prenyltransferase, MiaA, transfer ribonucleate isopentenyltransferase, Delta2-isopentenyl pyrophosphate:tRNA-Delta2-isopentenyl transferase, Delta2-isopentenyl pyrophosphate:transfer ribonucleic acid Delta2-isopentenyltransferase) is an enzyme with systematic name dimethylallyl-diphosphate: tRNA dimethylallyltransferase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

dimethylallyl diphosphate + tRNA

\rightleftharpoons

diphosphate + tRNA containing 6-dimethylallyladenosine

Formerly known as tRNA isopentenyltransferase (EC 2.5.1.8), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate.

References

↑ Leung, H.C., Chen, Y. and Winkler, M.E. (1997). "Regulation of substrate recognition by the MiaA tRNA prenyltransferase modification enzyme of Escherichia coli K-12". J. Biol. Chem. 272 (20): 13073–13083. doi:10.1074/jbc.272.20.13073. PMID 9148919.
↑ Soderberg, T. and Poulter, C.D. (2000). "Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: essential elements for recognition of tRNA substrates within the anticodon stem-loop". Biochemistry 39 (21): 6546–6553. doi:10.1021/bi992775u. PMID 10828971.
↑ Moore, J.A., Mathis, J.R. and Poulter, C.D. (2000). "Escherichia coli dimethylallyl diphosphate: tRNA dimethylallyltransferase: pre-steady-state kinetic studies". Biochim. Biophys. Acta 1479 (1–2): 166–174. doi:10.1016/S0167-4838(00)00031-5. PMID 11004538.

External links

TRNA dimethylallyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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