TXNIP

Thioredoxin interacting protein
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4GEI​, 4GEJ​, 4GFX​, 4LL1​, 4LL4​, 4ROF​, 4ROH​, 4ROI​, 4ROJ​, 4RRE​
Identifiers
Symbols	TXNIP ; EST01027; HHCPA78; THIF; VDUP1
External IDs	OMIM: 606599 MGI: 1889549 HomoloGene: 38186 GeneCards: TXNIP Gene
Gene ontology Molecular function • enzyme inhibitor activity • protein binding • ubiquitin protein ligase binding Cellular component • nucleus • cytoplasm • mitochondrial intermembrane space • cytosol Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • protein import into nucleus • cell cycle • response to mechanical stimulus • response to glucose • keratinocyte differentiation • response to estradiol • response to progesterone • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway • regulation of cell proliferation • response to drug • response to hydrogen peroxide • positive regulation of apoptotic process • negative regulation of catalytic activity • innate immune response • platelet-derived growth factor receptor signaling pathway • response to calcium ion • negative regulation of cell division • cellular response to tumor cell Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10628	56338
Ensembl	ENSG00000265972	ENSMUSG00000038393
UniProt	Q9H3M7	Q8BG60
RefSeq (mRNA)	NM_006472	NM_001009935
RefSeq (protein)	NP_006463	NP_001009935
Location (UCSC)	Chr 1: 145.99 – 146 Mb	Chr 3: 96.56 – 96.56 Mb
PubMed search

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.^[1][2]

Interactions

TXNIP has been shown to interact with Thioredoxin^[3] and ZBTB32.^[4]

Related gene problems

• TAR syndrome
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

References

1. Chen KS, DeLuca HF (Sep 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochimica Et Biophysica Acta 1219 (1): 26–32. doi:10.1016/0167-4781(94)90242-9. PMID 8086474.
2. "Entrez Gene: TXNIP thioredoxin interacting protein".
3. Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". The Journal of Biological Chemistry 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. PMID 10419473.
4. Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.

Further reading

• Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". The Journal of Biological Chemistry 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. PMID 10419473.
• Ludwig DL, Kotanides H, Le T, Chavkin D, Bohlen P, Witte L (May 2001). "Cloning, genetic characterization, and chromosomal mapping of the mouse VDUP1 gene". Gene 269 (1-2): 103–12. doi:10.1016/S0378-1119(01)00455-3. PMID 11376942.
• Bodnar JS, Chatterjee A, Castellani LW, Ross DA, Ohmen J, Cavalcoli J, Wu C, Dains KM, Catanese J, Chu M, Sheth SS, Charugundla K, Demant P, West DB, de Jong P, Lusis AJ (Jan 2002). "Positional cloning of the combined hyperlipidemia gene Hyplip1". Nature Genetics 30 (1): 110–6. doi:10.1038/ng811. PMC 2846781. PMID 11753387.
• Joguchi A, Otsuka I, Minagawa S, Suzuki T, Fujii M, Ayusawa D (Apr 2002). "Overexpression of VDUP1 mRNA sensitizes HeLa cells to paraquat". Biochemical and Biophysical Research Communications 293 (1): 293–7. doi:10.1016/S0006-291X(02)00208-5. PMID 12054598.
• Butler LM, Zhou X, Xu WS, Scher HI, Rifkind RA, Marks PA, Richon VM (Sep 2002). "The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin". Proceedings of the National Academy of Sciences of the United States of America 99 (18): 11700–5. doi:10.1073/pnas.182372299. PMC 129332. PMID 12189205.
• Schulze PC, De Keulenaer GW, Yoshioka J, Kassik KA, Lee RT (Oct 2002). "Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin". Circulation Research 91 (8): 689–95. doi:10.1161/01.RES.0000037982.55074.F6. PMID 12386145.
• Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.
• Champliaud MF, Viel A, Baden HP (Oct 2003). "The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes". The Journal of Investigative Dermatology 121 (4): 781–5. doi:10.1046/j.1523-1747.2003.12539.x. PMID 14632196.
• Kim KY, Shin SM, Kim JK, Paik SG, Yang Y, Choi I (Mar 2004). "Heat shock factor regulates VDUP1 gene expression". Biochemical and Biophysical Research Communications 315 (2): 369–75. doi:10.1016/j.bbrc.2004.01.047. PMID 14766217.
• Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT (Jul 2004). "Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein". The Journal of Biological Chemistry 279 (29): 30369–74. doi:10.1074/jbc.M400549200. PMID 15128745.
• Coon H, Singh N, Dunn D, Eckfeldt JH, Province MA, Hopkins PN, Weiss R, Hunt SC, Leppert MF (Jun 2004). "TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study". Atherosclerosis 174 (2): 357–62. doi:10.1016/j.atherosclerosis.2004.02.004. PMID 15136067.
• Nishinaka Y, Masutani H, Oka S, Matsuo Y, Yamaguchi Y, Nishio K, Ishii Y, Yodoi J (Sep 2004). "Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1". The Journal of Biological Chemistry 279 (36): 37559–65. doi:10.1074/jbc.M405473200. PMID 15234975.
• Aitken CJ, Hodge JM, Nishinaka Y, Vaughan T, Yodoi J, Day CJ, Morrison NA, Nicholson GC (Dec 2004). "Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling". Journal of Bone and Mineral Research 19 (12): 2057–64. doi:10.1359/JBMR.040913. PMID 15537450.
• Yamawaki H, Pan S, Lee RT, Berk BC (Mar 2005). "Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells". The Journal of Clinical Investigation 115 (3): 733–8. doi:10.1172/JCI200523001. PMC 546457. PMID 15696199.
• Minn AH, Hafele C, Shalev A (May 2005). "Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis". Endocrinology 146 (5): 2397–405. doi:10.1210/en.2004-1378. PMID 15705778.