Tabersonine 16-hydroxylase

tabersonine 16-hydroxylase
Identifiers
EC number	1.14.13.73
CAS number	250378-34-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a tabersonine 16-hydroxylase (EC 1.14.13.73) is an enzyme that catalyzes the chemical reaction

tabersonine + NADPH + H⁺ + O₂ $\rightleftharpoons$ 16-hydroxytabersonine + NADP⁺ + H₂O

The 4 substrates of this enzyme are tabersonine, NADPH, H⁺, and O₂, whereas its 3 products are 16-hydroxytabersonine, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating). Other names in common use include tabersonine-11-hydroxylase, and T11H. This enzyme participates in terpene indole and ipecac alkaloid biosynthesis.

References

• St-Pierre B, De Luca V (1995). "A Cytochrome P-450 Monooxygenase Catalyzes the First Step in the Conversion of Tabersonine to Vindoline in Catharanthus roseus". Plant. Physiol. 109 (1): 131–139. doi:10.1104/pp.109.1.131. PMC 157569. PMID 12228585.