Taurochenodeoxycholate 6α-hydroxylase

Taurochenodeoxycholate 6alpha-hydroxylase
Identifiers
EC number 1.14.13.97
CAS number 105669-85-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Taurochenodeoxycholate 6alpha-hydroxylase (EC 1.14.13.97, CYP3A4, CYP4A21, taurochenodeoxycholate 6alpha-monooxygenase) is an enzyme with systematic name taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

(1) taurochenodeoxycholate + NADPH + H+ + O2 \rightleftharpoons taurohyocholate + NADP+ + H2O
(2) lithocholate + NADPH + H+ + O2 \rightleftharpoons hyodeoxycholate + NADP+ + H2O

Taurochenodeoxycholate 6α-hydroxylase is a heme-thiolate protein (P-450).

See also

References

  1. ↑ Araya, Z. and Wikvall, K. (1999). "6α-Hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes". Biochim. Biophys. Acta 1438 (1): 47–54. doi:10.1016/s1388-1981(99)00031-1. PMID 10216279.
  2. ↑ Araya, Z., Hellman, U. and Hansson, R. (1995). "Characterisation of taurochenodeoxycholic acid 6α-hydroxylase from pig liver microsomes". Eur. J. Biochem. 231 (3): 855–861. doi:10.1111/j.1432-1033.1995.0855d.x. PMID 7649186.
  3. ↑ Kramer, W., Sauber, K., Baringhaus, K.H., Kurz, M., Stengelin, S., Lange, G., Corsiero, D., Girbig, F., Konig, W. and Weyland, C. (2001). "Identification of the bile acid-binding site of the ileal lipid-binding protein by photoaffinity labeling, matrix-assisted laser desorption ionization-mass spectrometry, and NMR structure". J. Biol. Chem. 276 (10): 7291–7301. doi:10.1074/jbc.M006877200. PMID 11069906.
  4. ↑ Lundell, K., Hansson, R. and Wikvall, K. (2001). "Cloning and expression of a pig liver taurochenodeoxycholic acid 6α-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily". J. Biol. Chem. 276 (13): 9606–9612. doi:10.1074/jbc.M006584200. PMID 11113117.
  5. ↑ Lundell, K. and Wikvall, K. (2003). "Gene structure of pig sterol 12α-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6α-hydroxylase (CYP4A21)". Biochim. Biophys. Acta 1634 (3): 86–96. doi:10.1016/j.bbalip.2003.09.002. PMID 14643796.
  6. ↑ Russell, D.W. (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annu. Rev. Biochem. 72: 137–174. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.

External links

This article is issued from Wikipedia - version of the Wednesday, March 30, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.