Terephthalate 1,2-cis-dihydrodiol dehydrogenase

terephthalate 1,2-cis-dihydrodiol dehydrogenase
Identifiers
EC number 1.3.1.61
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a terephthalate 1,2-cis-dihydrodiol dehydrogenase (EC 1.3.1.61) is an enzyme that catalyzes the chemical reaction

cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate + NAD+ \rightleftharpoons 3,4-dihydroxybenzoate + CO2 + NADH

Thus, the two substrates of this enzyme are cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate and NAD+, whereas its 3 products are 3,4-dihydroxybenzoate, CO2, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating). This enzyme participates in 2,4-dichlorobenzoate degradation.

References

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