Thermospermine synthase

Thermospermine synthase (EC 2.5.1.79, TSPMS, ACL5, SAC51) is an enzyme with systematic name S-adenosylmethioninamine:spermidine 3-aminopropyltransferase (thermospermine synthesizing).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

S-adenosylmethioninamine + spermidine

\rightleftharpoons

S-methyl-5'-thioadenosine + thermospermine + H⁺

This enzyme is required for correct xylem specification through regulation of the lifetime of the xylem elements.

References

↑ Romer, P., Faltermeier, A., Mertins, V., Gedrange, T., Mai, R. and Proff, P. (2008). "Investigations about N-aminopropyl transferases probably involved in biomineralization". J. Physiol. Pharmacol. 59 Suppl 5: 27–37. PMID 19075322.
↑ Knott, J.M., Romer, P. and Sumper, M. (2007). "Putative spermine synthases from Thalassiosira pseudonana and Arabidopsis thaliana synthesize thermospermine rather than spermine". FEBS Lett. 581 (16): 3081–3086. doi:10.1016/j.febslet.2007.05.074. PMID 17560575.
↑ Muniz, L., Minguet, E.G., Singh, S.K., Pesquet, E., Vera-Sirera, F., Moreau-Courtois, C.L., Carbonell, J., Blazquez, M.A. and Tuominen, H. (2008). "ACAULIS5 controls Arabidopsis xylem specification through the prevention of premature cell death". Development 135 (15): 2573–2582. doi:10.1242/dev.019349. PMID 18599510.

External links

Thermospermine synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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