Thymic hypoplasia

Thymic hypoplasia
Classification and external resources
Specialty	medical genetics
ICD-10	Q89.2 (note: thymus is classified as endocrine in ICD-10)
ICD-9-CM	759.2
DiseasesDB	34516

Thymic hypoplasia is a condition where the thymus is underdeveloped or involuted.

Calcium levels can be used to distinguish between the following two conditions associated with thymic hypoplasia:

22q11.2 deletion syndrome: hypocalcemia
Ataxia telangiectasia: normal levels of calcium

Lymphatic disease: Congenital lymphatic organ disorders (Q89.0/Q89.2, 759.0/759.2)

Thymus	Thymic hypoplasia DiGeorge syndrome Ectopic thymus

Spleen	Congenital asplenia/hyposplenism Asplenia with cardiovascular anomalies Accessory spleen Polysplenia

Immune disorders: Lymphoid and complement immunodeficiency (D80–D85, 279.0–4)

Primary

Antibody/humoral (B)

Hypogammaglobulinemia	X-linked agammaglobulinemia Transient hypogammaglobulinemia of infancy

Dysgammaglobulinemia	IgA deficiency IgG deficiency IgM deficiency Hyper IgM syndrome (1 2 3 4 5) Wiskott-Aldrich syndrome Hyper-IgE syndrome

Other	Common variable immunodeficiency ICF syndrome

T cell deficiency (T)

thymic hypoplasia: hypoparathyroid (Di George's syndrome)
euparathyroid (Nezelof syndrome
Ataxia telangiectasia)

peripheral: Purine nucleoside phosphorylase deficiency

Hyper IgM syndrome (1)

Severe combined (B+T)

x-linked: X-SCID
autosomal: Adenosine deaminase deficiency
Omenn syndrome
ZAP70 deficiency
Bare lymphocyte syndrome

Acquired

AIDS

Leukopenia:
Lymphocytopenia

Idiopathic CD4+ lymphocytopenia

Complement deficiency

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