MBL deficiency

MBL deficiency
Classification and external resources
OMIM	154545

MBL deficiency refers to Mannan-binding lectin pathway components such as MBL2.

It is thought that 5-10% of the population have an MBL deficiency of some degree^[1] There are varying degrees of MBL deficiency; some people in a given population will not even know they have the deficiency, while others may have such low levels that they suffer from infections with great frequency. Babies and young children are most at risk.

References

↑ http://ghr.nlm.nih.gov/condition/mannose-binding-lectin-deficiency

Immune disorders: Lymphoid and complement immunodeficiency (D80–D85, 279.0–4)

Primary

Antibody/humoral (B)

Hypogammaglobulinemia	X-linked agammaglobulinemia Transient hypogammaglobulinemia of infancy

Dysgammaglobulinemia	IgA deficiency IgG deficiency IgM deficiency Hyper IgM syndrome (1 2 3 4 5) Wiskott-Aldrich syndrome Hyper-IgE syndrome

Other	Common variable immunodeficiency ICF syndrome

T cell deficiency (T)

thymic hypoplasia: hypoparathyroid (Di George's syndrome)
euparathyroid (Nezelof syndrome
Ataxia telangiectasia)

peripheral: Purine nucleoside phosphorylase deficiency

Hyper IgM syndrome (1)

Severe combined (B+T)

x-linked: X-SCID
autosomal: Adenosine deaminase deficiency
Omenn syndrome
ZAP70 deficiency
Bare lymphocyte syndrome

Acquired

AIDS

Leukopenia:
Lymphocytopenia

Idiopathic CD4+ lymphocytopenia

Complement deficiency

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