Tombusvirus 3' UTR region IV
| Tombusvirus 3' UTR region IV | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of Tombus_3_IV | |
| Identifiers | |
| Symbol | Tombus_3_IV |
| Rfam | RF00176 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Viruses |
| SO | 0000205 |
Tombusvirus 3' UTR is an important cis-regulatory region of the Tombus virus genome.[1]
Tomato bushy stunt virus is the prototype member of the Tombusviridae family. The genome of this virus is positive sense single stranded RNA. Replication occurs via a negative strand RNA intermediate. In addition to viral proteins p33 and the RNA-dependent RNA polymerase p92, and unknown host factors, conserved and structural regions within the 3'untranslated region (3'UTR) are important for regulating genome replication. This 3' structural element contains a pseudoknot.[1][2]
Other non-coding RNA structures in Tombusvirus include the 5' UTR and an internal replcation element.[3]
References
- 1 2 Fabian MR, Na H, Ray D, White KA (2003). "3'-Terminal RNA secondary structures are important for accumulation of tomato bushy stunt virus DI RNAs". Virology 313 (2): 567–80. doi:10.1016/S0042-6822(03)00349-0. PMID 12954222.
- ↑ Pogany J, Fabian MR, White KA, Nagy PD (2003). "A replication silencer element in a plus-strand RNA virus". EMBO J. 22 (20): 5602–11. doi:10.1093/emboj/cdg523. PMC 213777. PMID 14532132.
- ↑ Monkewich, S; Lin HX; Fabian MR; Xu W; Na H; Ray D; Chernysheva OA; Nagy PD; White KA (2005). "The p92 Polymerase Coding Region Contains an Internal RNA Element Required at an Early Step in Tombusvirus Genome Replication". J Virol 79 (8): 4848–4858. doi:10.1128/JVI.79.8.4848-4858.2005. PMC 1069561. PMID 15795270.
External links
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