Trans,polycis-polyprenyl diphosphate synthase ((2Z,6E)-farnesyl diphosphate specific)

Trans,polycis-polyprenyl diphosphate synthase ((2Z,6E)-farnesyl diphosphate specific) (EC 2.5.1.88) is an enzyme with systematic name (2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 9--11 isopentenyl units).^[1] This enzyme catalyses the following chemical reaction

(2Z,6E)-farnesyl diphosphate + n isopentenyl diphosphate

\rightleftharpoons

n diphosphate + trans,polycis-polyprenyl diphosphate (n = 9 - 11)

This enzyme has the highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate.

References

↑ Ambo, T., Noike, M., Kurokawa, H. and Koyama, T. (2009). "Cloning and functional analysis of cis-prenyltransferase from Thermobifida fusca". J. Biosci. Bioeng. 107 (6): 620–622. doi:10.1016/j.jbiosc.2009.02.006. PMID 19447338.

External links

Trans,polycis-polyprenyl diphosphate synthase ((2Z,6E)-farnesyl diphosphate specific) at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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