Tricetin 3',4',5'-O-trimethyltransferase
Tricetin 3',4',5'-O-trimethyltransferase (EC 2.1.1.169, FOMT, TaOMT1, TaCOMT1, TaOMT2) is an enzyme with systematic name S-adenosyl-L-methionine:tricetin 3',4',5'-O-trimethyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- 3 S-adenosyl-L-methionine + tricetin
3 S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin (overall reaction)
- (1a) S-adenosyl-L-methionine + tricetin
S-adenosyl-L-homocysteine + 3'-O-methyltricetin
- (1b) S-adenosyl-L-methionine + 3'-O-methyltricetin
S-adenosyl-L-homocysteine + 3',5'-O-dimethyltricetin
- (1c) S-adenosyl-L-methionine + 3',5'-O-dimethyltricetin
S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin
The enzyme from Triticum aestivum catalyses the sequential O-methylation of tricetin via 3'-O-methyltricetin, 3',5'-O-methyltricetin to 3',4',5'-O-trimethyltricetin.
References
- ↑ Kornblatt, J.A., Zhou, J.M. and Ibrahim, R.K. (2008). "Structure-activity relationships of wheat flavone O-methyltransferase: a homodimer of convenience". FEBS J. 275: 2255–2266. doi:10.1111/j.1742-4658.2008.06377.x. PMID 18397325.
- ↑ Zhou, J.M., Gold, N.D., Martin, V.J., Wollenweber, E. and Ibrahim, R.K. (2006). "Sequential O-methylation of tricetin by a single gene product in wheat". Biochim. Biophys. Acta 1760: 1115–1124. doi:10.1016/j.bbagen.2006.02.008. PMID 16730127.
- ↑ Zhou, J.M., Seo, Y.W. and Ibrahim, R.K. (2009). "Biochemical characterization of a putative wheat caffeic acid O-methyltransferase". Plant Physiol. Biochem. 47: 322–326. doi:10.1016/j.plaphy.2008.11.011. PMID 19211254.
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