Trimedoxime bromide

Trimedoxime bromide
Systematic (IUPAC) name

1,1′-propane-1,3-diylbis{4-[(E)-(hydroxyimino)methyl]pyridinium} dibromide
Clinical data
Legal status	Experimental In military use
Routes of administration	Intramuscular injection
Pharmacokinetic data
Biological half-life	2 hours (mean)
Identifiers
CAS Number	56-97-3
ATC code	None
PubChem	CID 5359236
ChemSpider	4514238
UNII	ED0GXI9825^Y
Chemical data
Formula	C₁₅H₁₈Br₂N₄O₂
Molar mass	446.14 g/mol

Trimedoxime bromide (INN), also known as dipyroxime or TMB-4, is an oxime used in the treatment of organophosphate poisoning.

Antidotes (V03AB)

Nervous
system

Nerve agent / Organophosphate poisoning	Atropine^# Biperiden Diazepam^# Oximes Obidoxime Pralidoxime see also: Cholinesterase

Barbiturate overdose	Bemegride Ethamivan

Benzodiazepine overdose	Cyprodenate Flumazenil

GHB overdose	Physostigmine SCH-50911

Opioid overdose	Diprenorphine Doxapram Nalmefene Nalorphine Naloxone^# Naltrexone

Reversal of neuromuscular blockade	Sugammadex

Circulatory
system

Beta blocker	Glucagon

Digoxin toxicity	Digoxin Immune Fab

Heparin	Protamine^#

Other

Arsenic poisoning	Dimercaprol^# Succimer

Cyanide poisoning	4-Dimethylaminophenol Hydroxocobalamin nitrite Amyl nitrite Sodium nitrite^# Sodium thiosulfate^#

Hydrofluoric acid	Calcium gluconate^#

Methanol / Ethylene glycol poisoning	Primary alcohols: Ethanol Fomepizole

Paracetamol toxicity (Acetaminophen)	Acetylcysteine^# Glutathione Methionine^#

Toxic metals (cadmium lead mercury thallium)	Dimercaprol^# Edetates Prussian blue^#

Other	iodine-131 Potassium iodide Methylthioninium chloride^# oxidizing agent Potassium permanganate Prednisolone/promethazine

Emetic

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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