Tromantadine

Tromantadine

Systematic (IUPAC) name
N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide
Clinical data
Trade names	Viru-Merz
AHFS/Drugs.com	International Drug Names
Routes of administration	Topical (gel)
Legal status
Legal status	US: Not FDA-approved OTC (RU)
Identifiers
CAS Number	53783-83-8
ATC code	D06BB02 (WHO) J05AC03
PubChem	CID 64377
ChemSpider	57947
UNII	H191JFG8WA
KEGG	D07199
NIAID ChemDB	007760
Chemical data
Formula	C16H28N2O2
Molar mass	280.406 g/mol
SMILES O=C(NC13CC2CC(CC(C1)C2)C3)COCCN(C)C
InChI InChI=1S/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19) Key:UXQDWARBDDDTKG-UHFFFAOYSA-N
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Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade names Viru-Merz and Viru-Merz Serol. Its performance is similar to aciclovir.

Like rimantadine, amantadine, and adapromine, tromantadine is a derivative of adamantane.

Mechanism

Tromantadine inhibits the early and late events in the virus replication cycle.^[1] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.

References

1. Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrob. Agents Chemother. 22 (6): 1031–6. doi:10.1128/aac.22.6.1031. PMC 185716. PMID 6297383.

External links

• Viru-Merz website