Tyrosine—arginine ligase

tyrosine-arginine ligase
Identifiers
EC number	6.3.2.24
CAS number	116036-78-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a tyrosine-arginine ligase (EC 6.3.2.24) is an enzyme that catalyzes the chemical reaction

ATP + L-tyrosine + L-arginine $\rightleftharpoons$ AMP + diphosphate + L-tyrosyl-L-arginine

The 3 substrates of this enzyme are ATP, L-tyrosine, and L-arginine, whereas its 3 products are AMP, diphosphate, and L-tyrosyl-L-arginine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-tyrosine:L-arginine ligase (AMP-forming). Other names in common use include tyrosyl-arginine synthase, kyotorphin synthase, kyotorphin-synthesizing enzyme, and kyotorphin synthetase.

References

• Ueda, H.; Yoshihara, Y.; Fukushima, N.; Shiomi, H.; Nakamura, A.; Takagi, H. (Jun 1987). "Kyotorphin (tyrosine-arginine) synthetase in rat brain synaptosomes". J. Biol. Chem. 262 (17): 8165–73. ISSN 0021-9258. PMID 3597366.