U7 small nuclear RNA

U7 small nuclear RNA
Predicted secondary structure and sequence conservation of U7
Identifiers
Symbol U7
Rfam RF00066
Other data
RNA type Gene; snRNA
Domain(s) Eukaryota
SO 0000274

The U7 small nuclear RNA (U7 snRNA) is an RNA molecule and a component of the small nuclear ribonucleoprotein complex (U7 snRNP). The U7 snRNA is required for histone pre-mRNA processing.

The 5' end of the U7 snRNA binds the HDE (Histone Downstream Element), a conserved purine-rich region, located 15 nucleotides downstream the histone mRNA cleavage site.[1][2] The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future recruitment of cleavage factors during histone pre-mRNA processing.[3]

See also

References

  1. ↑ Spycher C, Streit A, Stefanovic B, Albrecht D, Koning TH, Schümperli D (1994). "3' end processing of mouse histone pre-mRNA: evidence for additional base-pairing between U7 snRNA and pre-mRNA". Nucleic Acids Res 22 (20): 4023–4030. doi:10.1093/nar/22.20.4023. PMC 331885. PMID 7937126.
  2. ↑ Mowry KL, Steitz JA (1987). "Identification of the human U7 snRNP as one of several factors involved in the 3' end maturation of histone premessenger RNA's". Science 238 (4834): 1682–1687. doi:10.1126/science.2825355. PMID 2825355.
  3. ↑ Marzluff, William F.; Wagner, Eric J.; Duronio, Robert J. "Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail". Nature Reviews Genetics 9 (11): 843–854. doi:10.1038/nrg2438. PMC 2715827. PMID 18927579.

Further reading

External links

  1. ↑ Voigt T, Meyer K, Baum O, Schümperli D (2010). "Ultrastructural changes in diaphragm neuromuscular junctions in a severe mouse model for Spinal Muscular Atrophy and their prevention by bifunctional U7 snRNA correcting SMN2 splicing". Neuromuscul Disord 20 (11): 744–752. doi:10.1016/j.nmd.2010.06.010. PMID 20832308.
  2. ↑ Ruepp MD, Vivarelli S, Pillai RS, Kleinschmidt N, Azzouz TN, Barabino SM, Schümperli D (2010). "The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs". Nucleic Acids Res 38 (21): 7637–7650. doi:10.1093/nar/gkq613. PMC 2995043. PMID 20634199.
  3. ↑ Geib T, Hertel KJ (2009). Valcarcel, Juan, ed. "Restoration of full-length SMN promoted by adenoviral vectors expressing RNA antisense oligonucleotides embedded in U7 snRNAs". PLoS ONE 4 (12): e8204. doi:10.1371/journal.pone.0008204. PMC 2781471. PMID 19997596.
  4. ↑ Godfrey AC, White AE, Tatomer DC, Marzluff WF, Duronio RJ (2009). "The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development". RNA 15 (9): 1661–1672. doi:10.1261/rna.1518009. PMC 2743060. PMID 19620235.
  5. ↑ Yang XC, Torres MP, Marzluff WF, Dominski Z (2009). "Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA". Mol Cell Biol 29 (15): 4045–4056. doi:10.1128/MCB.00296-09. PMC 2715809. PMID 19470752.
  6. ↑ Goyenvalle A, Babbs A, van Ommen GJ, Garcia L, Davies KE (2009). "Enhanced exon-skipping induced by U7 snRNA carrying a splicing silencer sequence: Promising tool for DMD therapy". Mol Ther 17 (7): 1234–1240. doi:10.1038/mt.2009.113. PMC 2835201. PMID 19455105.
  7. ↑ Meyer K, Marquis J, Trüb J, Nlend Nlend R, Verp S, Ruepp MD, Imboden H, Barde I, Trono D, Schümperli D (2009). "Rescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulation". Hum Mol Genet 18 (3): 546–555. doi:10.1093/hmg/ddn382. PMID 19010792.
  8. ↑ Marquis J, Kämpfer SS, Angehrn L, Schümperli D (2009). "Doxycycline-controlled splicing modulation by regulated antisense U7 snRNA expression cassettes". Gene Ther 16 (1): 70–77. doi:10.1038/gt.2008.138. PMID 18701908.
  9. ↑ Marz M, Mosig A, Stadler BM, Stadler PF (2007). "U7 snRNAs: a computational survey". Genomics Proteomics Bioinformatics 5 (3–4): 187–195. doi:10.1016/S1672-0229(08)60006-6. PMID 18267300.
  10. ↑ Higuchi T, Anzai K, Kobayashi S (2008). "U7 snRNA acts as a transcriptional regulator interacting with an inverted CCAAT sequence-binding transcription factor NF-Y". Biochim Biophys Acta 1780 (2): 274–281. doi:10.1016/j.bbagen.2007.11.005. PMID 18078822.
  11. ↑ Friend K, Lovejoy AF, Steitz JA (2007). "U2 snRNP binds intronless histone pre-mRNAs to facilitate U7-snRNP-dependent 3' end formation". Mol Cell 28 (2): 240–252. doi:10.1016/j.molcel.2007.09.026. PMC 2149891. PMID 17964263.
  12. ↑ Uchikawa H, Fujii K, Kohno Y, Katsumata N, Nagao K, Yamada M, Miyashita T (2007). "U7 snRNA-mediated correction of aberrant splicing caused by activation of cryptic splice sites". J Hum Genet 52 (11): 891–897. doi:10.1007/s10038-007-0192-8. PMID 17851636.
  13. ↑ Marquis J, Meyer K, Angehrn L, Kämpfer SS, Rothen-Rutishauser B, Schümperli D (2007). "Spinal muscular atrophy: SMN2 pre-mRNA splicing corrected by a U7 snRNA derivative carrying a splicing enhancer sequence". Mol Ther 15 (8): 1479–1486. doi:10.1038/sj.mt.6300200. PMID 17505471.
  14. ↑ Asparuhova MB, Marti G, Liu S, Serhan F, Trono D, Schümperli D (2007). "Inhibition of HIV-1 multiplication by a modified U7 snRNA inducing Tat and Rev exon skipping". J Gene Med 9 (5): 323–334. doi:10.1002/jgm.1027. PMID 17474072.
  15. ↑ Scheuerbrandt G (2006). "Exon skipping with U7 gene transfer". Acta Myol 25 (1): 40–2. PMID 17039980.
  16. ↑ Jaeger S, Martin F, Rudinger-Thirion J, Giegé R, Eriani G (2006). "Binding of human SLBP on the 3'-UTR of histone precursor H4-12 mRNA induces structural rearrangements that enable U7 snRNA anchoring". Nucleic Acids Res 34 (17): 4987–4995. doi:10.1093/nar/gkl666. PMC 1635294. PMID 16982637.
  17. ↑ Wagner EJ, Marzluff WF (2006). "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase". Mol Cell Biol 26 (17): 6702–6712. doi:10.1128/MCB.00391-06. PMC 1592837. PMID 16914750.
  18. ↑ Kolev NG, Steitz JA (2006). "In vivo assembly of functional U7 snRNP requires RNA backbone flexibility within the Sm-binding site". Nat Struct Mol Biol 13 (4): 347–353. doi:10.1038/nsmb1075. PMID 16547514.
  19. ↑ Godfrey AC, Kupsco JM, Burch BD, Zimmerman RM, Dominski Z, Marzluff WF, Duronio RJ (2006). "U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis". RNA 12 (3): 396–409. doi:10.1261/rna.2270406. PMC 1383579. PMID 16495235.
  20. ↑ Madocsai C, Lim SR, Geib T, Lam BJ, Hertel KJ (2005). "Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs". Mol Ther 12 (6): 1013–1022. doi:10.1016/j.ymthe.2005.08.022. PMID 16226920.
  21. ↑ Azzouz TN, Pillai RS, Däpp C, Chari A, Meister G, Kambach C, Fischer U, Schümperli D (2005). "Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes". J Biol Chem 280 (41): 34435–34440. doi:10.1074/jbc.M505077200. PMID 16087681.
  22. ↑ Azzouz TN, Gruber A, Schümperli D (2005). "U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA 3' end processing". Nucleic Acids Res 33 (7): 2106–2117. doi:10.1093/nar/gki516. PMC 1075925. PMID 15824063.
  23. ↑ Goyenvalle A, Vulin A, Fougerousse F, Leturcq F, Kaplan JC, Garcia L, Danos O (2004). "Rescue of dystrophic muscle through U7 snRNA-mediated exon skipping". Science 306 (5702): 1796–1799. doi:10.1126/science.1104297. PMID 15528407.
  24. ↑ Schümperli D, Pillai RS (2004). "The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein". Cell Mol Life Sci 61 (19–20): 2560–2570. doi:10.1007/s00018-004-4190-0. PMID 15526162.
  25. ↑ Liu S, Asparuhova M, Brondani V, Ziekau I, Klimkait T, Schümperli D (2004). "Inhibition of HIV-1 multiplication by antisense U7 snRNAs and siRNAs targeting cyclophilin A". Nucleic Acids Res 32 (12): 3752–3759. doi:10.1093/nar/gkh715. PMC 484190. PMID 15254276.
  26. ↑ Azzouz TN, Schumperli D (2003). "Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster". RNA 9 (12): 1532–1541. doi:10.1261/rna.5143303. PMC 1370506. PMID 14624008.
  27. ↑ Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D (2003). "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing". Genes Dev 17 (18): 2321–2333. doi:10.1101/gad.274403. PMC 196468. PMID 12975319.
  28. ↑ Dominski Z, Yang XC, Purdy M, Marzluff WF (2003). "Cloning and characterization of the Drosophila U7 small nuclear RNA". Proc Natl Acad Sci U S A 100 (16): 9422–9427. doi:10.1073/pnas.1533509100. PMC 170934. PMID 12872004.
  29. ↑ Brun C, Suter D, Pauli C, Dunant P, Lochmüller H, Burgunder JM, Schümperli D, Weis J (2003). "U7 snRNAs induce correction of mutated dystrophin pre-mRNA by exon skipping". Cell Mol Life Sci 60 (3): 557–566. doi:10.1007/s000180300047. PMID 12737315.
  30. ↑ Dominski Z, Erkmann JA, Yang X, Sànchez R, Marzluff WF (2002). "A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing". Genes Dev 16 (1): 58–71. doi:10.1101/gad.932302. PMC 155312. PMID 11782445.
  31. ↑ Pillai RS, Will CL, Lührmann R, Schümperli D, Müller B (2001). "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein". EMBO J 20 (19): 5470–5479. doi:10.1093/emboj/20.19.5470. PMC 125645. PMID 11574479.
  32. ↑ Müller B, Link J, Smythe C (2000). "Assembly of U7 small nuclear ribonucleoprotein particle and histone RNA 3' processing in Xenopus egg extracts". J Biol Chem 275 (32): 24284–24293. doi:10.1074/jbc.M003253200. PMID 10827192.
  33. ↑ Tuma RS, Roth MB (1999). "Induction of coiled body-like structures in Xenopus oocytes by U7 snRNA". Chromosoma 108 (6): 337–344. doi:10.1007/s004120050385. PMID 10591993.
  34. ↑ Suter D, Tomasini R, Reber U, Gorman L, Kole R, Schümperli D (1999). "Double-target antisense U7 snRNAs promote efficient skipping of an aberrant exon in three human beta-thalassemic mutations". Hum Mol Genet 8 (13): 2415–2423. doi:10.1093/hmg/8.13.2415. PMID 10556289.
  35. ↑ Jacobs EY, Frey MR, Wu W, Ingledue TC, Gebuhr TC, Gao L, Marzluff WF, Matera AG (1999). "Coiled bodies preferentially associate with U4, U11, and U12 small nuclear RNA genes in interphase HeLa cells but not with U6 and U7 genes". Mol Biol Cell 10 (5): 1653–63. doi:10.1091/mbc.10.5.1653. PMC 30488. PMID 10233169.
  36. ↑ Dominski Z, Zheng LX, Sanchez R, Marzluff WF (1999). "Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA". Mol Cell Biol 19 (5): 3561–70. PMC 84148. PMID 10207079.
  37. ↑ Müller B, Schümperli D (1997). "The U7 snRNP and the hairpin binding protein: Key players in histone mRNA metabolism". Semin Cell Dev Biol 8 (6): 567–576. doi:10.1006/scdb.1997.0182. PMID 9642171.
  38. ↑ Gorman L, Suter D, Emerick V, Schümperli D, Kole R (1998). "Stable alteration of pre-mRNA splicing patterns by modified U7 small nuclear RNAs". Proc Natl Acad Sci U S A 95 (9): 4929–4934. doi:10.1073/pnas.95.9.4929. PMC 20190. PMID 9560205.
  39. ↑ Scharl EC, Steitz JA (1996). "Length suppression in histone messenger RNA 3'-end maturation: processing defects of insertion mutant premessenger RNAs can be compensated by insertions into the U7 small nuclear RNA". Proc Natl Acad Sci U S A 93 (25): 14659–14664. doi:10.1073/pnas.93.25.14659. PMC 26191. PMID 8962110.
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