U98 small nucleolar RNA

Small nucleolar RNA SNORA16B/SNORA16A family
Predicted secondary structure and sequence conservation of SNORA16
Identifiers
Symbol SNORA16
Alt. Symbols U98
Rfam RF00190
Other data
RNA type Gene; snRNA; snoRNA; H/ACA-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000594

U98 small nucleolar RNA also is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a "guide" RNA.

U98 belongs to the H/ACA box class of snoRNAs which are thought to guide the sites of modification of uridines to pseudouridines, the target for this family is unknown.[1][2] The mouse homologue was cloned and is called MBII-367.[3]

References

  1. ↑ Vitali, Patrice; Royo, Hélène; Seitz, Hervé; Bachellerie, Jean‐Pierre; Hüttenhofer, Alexander; Cavaillé, Jérôme (15 November 2003). "Identification of 13 novel human modification guide RNAs". Nucleic Acids Research 31 (22): 6543–6551. doi:10.1093/nar/gkg849. PMC 275545. PMID 14602913.
  2. ↑ Ganot, Philippe; Caizergues-Ferrer, Michèle; Kiss, Tamás (1 April 1997). "The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation". Genes & Development 11 (7): 941–956. doi:10.1101/gad.11.7.941. PMID 9106664.
  3. ↑ Huttenhofer, Alexander; Kiefmann, Martin; Meier-Ewert, Sebastian; O'Brien, John; Lehrach, Hans; Bachellerie, Jean-Pierre; Brosius, Jürgen (1 June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.

External links


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