UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase

UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase (EC 5.1.3.23, UDP-GlcNAc3NAcA 2-epimerase, UDP-alpha-D-GlcNAc3NAcA 2-epimerase, 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase, WbpI, WlbD) is an enzyme with systematic name 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate 2-epimerase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate

\rightleftharpoons

UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate

This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA.

References

↑ Westman, E.L., McNally, D.J., Rejzek, M., Miller, W.L., Kannathasan, V.S., Preston, A., Maskell, D.J., Field, R.A., Brisson, J.R. and Lam, J.S. (2007). "Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-α-D-glucuronic acid 2-epimerases from respiratory pathogens". Biochem. J. 405 (1): 123–130. doi:10.1042/BJ20070017. PMID 17346239.
↑ Westman, E.L., McNally, D.J., Rejzek, M., Miller, W.L., Kannathasan, V.S., Preston, A., Maskell, D.J., Field, R.A., Brisson, J.R. and Lam, J.S. (2007). "Erratum report: Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-α-D-glucuronic acid 2-epimerases from respiratory pathogens". Biochem. J. 405: 625–625.
↑ Sri Kannathasan, V., Staines, A.G., Dong, C.J., Field, R.A., Preston, A.G., Maskell, D.J. and Naismith, J.H. (2001). "Overexpression, purification, crystallization and data collection on the Bordetella pertussis wlbD gene product, a putative UDP-GlcNAc 2′-epimerase". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 9): 1310–1312. doi:10.1107/s0907444901010885. PMID 11526328.

External links

UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase at the US National Library of Medicine Medical Subject Headings (MeSH)

Isomerases: Epimerase and racemases (EC 5.1)

5.1.1: Amino acids	Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing) Serine racemase

5.1.2: Hydroxy acids	Mandelate racemase

5.1.3: Carbohydrates	UDP-glucose 4-epimerase

5.1.99: Other	Methylmalonyl CoA epimerase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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