UDP-glucuronic acid dehydrogenase

UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)
Identifiers
EC number	1.1.1.305
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) (EC 1.1.1.305, UDP-GlcUA decarboxylase, ArnADH) is an enzyme with systematic name UDP-glucuronate:NAD⁺ oxidoreductase (decarboxylating).^{[1][2][3][4][5]} This enzyme catalyses the following chemical reaction

UDP-glucuronate + NAD⁺ $\rightleftharpoons$ UDP-beta-L-threo-pentapyranos-4-ulose + CO₂ + NADH + H⁺

The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13 (UDP-4-amino-4-deoxy-L-arabinose formyltransferase).

References

1. Breazeale, S.D., Ribeiro, A.A., McClerren, A.L. and Raetz, C.R.H. (2005). "A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-amino-4-deoxy-L-arabinose. Identification and function of UDP-4-deoxy-4-formamido-L-arabinose". J. Biol. Chem. 280 (14): 14154–14167. doi:10.1074/jbc.M414265200. PMID 15695810.
2. Gatzeva-Topalova, P.Z., May, A.P. and Sousa, M.C. (2004). "Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance". Biochemistry 43 (42): 13370–13379. doi:10.1021/bi048551f. PMC 2680612. PMID 15491143.
3. Williams, G.J., Breazeale, S.D., Raetz, C.R.H. and Naismith, J.H. (2005). "Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis". J. Biol. Chem. 280 (24): 23000–23008. doi:10.1074/jbc.M501534200. PMC 3326539. PMID 15809294.
4. Gatzeva-Topalova, P.Z., May, A.P. and Sousa, M.C. (2005). "Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance". Structure 13 (6): 929–942. doi:10.1016/j.str.2005.03.018. PMC 2997725. PMID 15939024.
5. Yan, A., Guan, Z. and Raetz, C.R.H. (2007). "An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli". J. Biol. Chem. 282 (49): 36077–36089. doi:10.1074/jbc.M706172200. PMC 2613183. PMID 17928292.

External links

• UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) at the US National Library of Medicine Medical Subject Headings (MeSH)