UQCRH

Ubiquinol-cytochrome c reductase hinge protein
PDB rendering based on 1bcc.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1bcc​, 1be3​, 1bgy​, 1l0l​, 1l0n​, 1ntk​, 1ntm​, 1ntz​, 1nu1​, 1pp9​, 1ppj​, 1qcr​, 1sqb​, 1sqp​, 1sqq​, 1sqv​, 1sqx​, 2a06​, 2bcc​, 2fyu​, 3bcc​
Identifiers
Symbols	UQCRH ; QCR6; UQCR8
External IDs	OMIM: 613844 MGI: 1913826 HomoloGene: 103848 GeneCards: UQCRH Gene
EC number	1.10.2.2
Gene ontology Molecular function • protein binding • ubiquinol-cytochrome-c reductase activity Cellular component • mitochondrion • mitochondrial inner membrane • mitochondrial respiratory chain Biological process • oxidative phosphorylation • mitochondrial electron transport, ubiquinol to cytochrome c • aerobic respiration • respiratory electron transport chain • cellular metabolic process • small molecule metabolic process • oxidation-reduction process • hydrogen ion transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7388	66576
Ensembl	ENSG00000173660	ENSMUSG00000063882
UniProt	P07919	P99028
RefSeq (mRNA)	NM_001297565	NM_025641
RefSeq (protein)	NP_001284494	NP_079917
Location (UCSC)	Chr 1: 46.3 – 46.32 Mb	Chr 4: 116.07 – 116.08 Mb
PubMed search

Cytochrome b-c1 complex subunit 6, mitochondrial is a protein that in humans is encoded by the UQCRH gene.^[1][2]

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex; E.C. 1.10.2.2), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and "Rieske-associated protein".

References

1. Ohta S, Goto K, Arai H, Kagawa Y (Jan 1988). "An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein". FEBS Lett 226 (1): 171–5. doi:10.1016/0014-5793(87)80573-2. PMID 2826252.
2. "Entrez Gene: UQCRH ubiquinol-cytochrome c reductase hinge protein".

Further reading

• Liu AY, Bradner RC (1993). "Elevated expression of the human mitochondrial hinge protein gene in cancer.". Cancer Res. 53 (11): 2460–5. PMID 7684318.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Modena P, Testi MA, Facchinetti F, et al. (2003). "UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines". Oncogene 22 (29): 4586–93. doi:10.1038/sj.onc.1206472. PMID 12881716.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radic. Biol. Med. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.