USP26
| ubiquitin specific peptidase 26 | |
|---|---|
| Identifiers | |
| Symbol | USP26 |
| Entrez | 83844 |
| HUGO | 13485 |
| OMIM | 300309 |
| RefSeq | NM_031907 |
| UniProt | Q9BXU7 |
| Other data | |
| EC number | 3.1.2.15 |
| Locus | Chr. X q26.2 |
USP26 is a peptidase enzyme. The USP26 gene is an X-linked gene exclusively expressed in the testis and it codes for the ubiquitin-specific protease 26.[1]
Recent research has suggested that defects in USP26 may be involved in some cases of male infertility,[1][2] specifically Sertoli cell-only syndrome, and an absence of sperm in the ejaculate (azoospermia).[3]
See also
References
- 1 2 Stouffs K, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I (Mar 2005). "Possible role of USP26 in patients with severely impaired spermatogenesis". European Journal of Human Genetics 13 (3): 336–40. doi:10.1038/sj.ejhg.5201335. PMID 15562280.
- ↑ Zhang J, Qiu SD, Li SB, Zhou DX, Tian H, Huo YW, Ge L, Zhang QY (Nov 2007). "Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility". Asian Journal of Andrology 9 (6): 809–14. doi:10.1111/j.1745-7262.2007.00305.x. PMID 17968467.
- ↑ Ravel C, El Houate B, Chantot S, Lourenço D, Dumaine A, Rouba H, Bandyopadahyay A, Radhakrishna U, Das B, Sengupta S, Mandelbaum J, Siffroi JP, McElreavey K (Oct 2006). "Haplotypes, mutations and male fertility: the story of the testis-specific ubiquitin protease USP26". Molecular Human Reproduction 12 (10): 643–6. doi:10.1093/molehr/gal063. PMID 16888075.
External links
- USP26 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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