Uracil/thymine dehydrogenase

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Uracil/thymine dehydrogenase (EC 1.17.99.4, uracil oxidase, uracil-thymine oxidase, uracil dehydrogenase) is an enzyme with systematic name uracil:acceptor oxidoreductase.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

(1) uracil + H₂O + acceptor

\rightleftharpoons

barbiturate + reduced acceptor

(2) thymine + H₂O + acceptor

\rightleftharpoons

5-methylbarbiturate + reduced acceptor

Uracil/thymine dehydrogenase forms part of the oxidative pyrimidine-degrading pathway in some microorganisms.

References

↑ Hayaishi, O. and Kornberg, A. (1952). "Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes". J. Biol. Chem. 197 (2): 717–723. PMID 12981104.
↑ Wang, T.P. and Lampen, J.O. (1952). "Metabolism of pyrimidines by a soil bacterium". J. Biol. Chem. 194 (2): 775–783. PMID 14927671.
↑ Wang, T.P. and Lampen, J.O. (1952). "Uracil oxidase and the isolation of barbituric acid from uracil oxidation". J. Biol. Chem. 194 (2): 785–791. PMID 14927672.
↑ Lara, F.J.S. (1952). "On the decomposition of pyrimidines by bacteria. II. Studies with cell-free enzyme preparations". J. Bacteriol. 64 (2): 279–285. PMID 14955523.
↑ Soong, C.L., Ogawa, J. and Shimizu, S. (2001). "Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase". Biochem. Biophys. Res. Commun. 286: 222–226. doi:10.1006/bbrc.2001.5356. PMID 11485332.

External links

Uracil/thymine dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)

Other oxidoreductases (EC 1.15-1.21)

1.15: Acting on superoxide as acceptor	Superoxide dismutase SOD1 SOD2 SOD3

1.16: Oxidizing metal ions	Ceruloplasmin

1.17: Acting on CH or CH2 groups	Xanthine oxidase Ribonucleotide reductase 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase

1.18: Acting on iron-sulfur proteins as donors	Nitrogenase

1.19: Acting on reduced flavodoxin as donor	Nitrogenase (flavodoxin)

1.20: Acting on phosphorus or arsenic in donors	Glutaredoxin GLRX GLRX2 GLRX3 GLRX5

1.21: Acting on X-H and Y-H to form an X-Y bond	Isopenicillin N synthase Columbamine oxidase Reticuline oxidase Sulochrin oxidase (+)-bisdechlorogeodin-forming (-)-bisdechlorogeodin-forming Aureusidin synthase Tetrahydrocannabinolic acid synthase Cannabidiolic acid synthase Dichlorochromopyrrolate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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