Ureidoglycolate hydrolase

ureidoglycolate hydrolase
Identifiers
EC number	3.5.3.19
CAS number	115629-07-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an ureidoglycolate hydrolase (EC 3.5.3.19) is an enzyme that catalyzes the chemical reaction

(S)-ureidoglycolate + H₂O $\rightleftharpoons$ glyoxylate + 2 NH₃ + CO₂

Thus, the two substrates of this enzyme are (S)-ureidoglycolate and H₂O, whereas its 3 products are glyoxylate, NH₃, and CO₂.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is (S)-ureidoglycolate amidohydrolase (decarboxylating). This enzyme participates in purine metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1XSQ, 1XSR, 1YQC, and 2BDR.

References

• Winkler RG, Blevins DG and Randall DD (1988). "Ureide catabolism in soybeans. III. Ureidoglycolate amidohydrolase and allantoate amidohydrolase are activities of an allantoate degrading enzyme complex". Plant Physiol. 86 (4): 1084–1088. doi:10.1104/pp.86.4.1084.