Uroporphyrinogen-III C-methyltransferase

Uroporphyrinogen-III C-methyltransferase
Identifiers
EC number	2.1.1.107
CAS number	125752-76-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Uroporphyrinogen-III C-methyltransferase (EC 2.1.1.107, uroporphyrinogen methyltransferase, uroporphyrinogen-III methyltransferase, adenosylmethionine-uroporphyrinogen III methyltransferase, S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase, uroporphyrinogen-III methylase, SirA, CysG, uroporphyrin-III C-methyltransferase, S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase.^[1][2][3] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + uroporphyrinogen III $\rightleftharpoons$ 2 S-adenosyl-L-homocysteine + precorrin-2 (overall reaction)

(1a) S-adenosyl-L-methionine + uroporphyrinogen III $\rightleftharpoons$ S-adenosyl-L-homocysteine + precorrin-1

(1b) S-adenosyl-L-methionine + precorrin-1 $\rightleftharpoons$ S-adenosyl-L-homocysteine + precorrin-2

Uroporphyrinogen-III C-methyltransferase catalyses two methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2.

References

1. Warren, M.J., Gonzalez, M.D., Williams, H.J., Stolowich, N.J. and Scott, A.I. (1990). "Uroporphyrinogen-III methylase catalyzes the enzymatic-synthesis of sirohydrochlorin-II and sirohydrochlorin-IV by a clockwise mechanism". J. Am. Chem. Soc. 112: 5343–5345. doi:10.1021/ja00169a048.
2. Warren, M.J., Roessner, C.A., Santander, P.J. and Scott, A.I. (1990). "The Escherichia coli cysG gene encodes S-adenosylmethionine-dependent uroporphyrinogen III methylase". Biochem. J. 265 (3): 725–729. PMID 2407234.
3. Schubert, H.L., Raux, E., Brindley, A.A., Leech, H.K., Wilson, K.S., Hill, C.P. and Warren, M.J. (2002). "The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase". EMBO J. 21: 2068–2075. doi:10.1093/emboj/21.9.2068. PMC 125995. PMID 11980703.

External links

• Uroporphyrinogen-III C-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)