WFIKKN2

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WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 is a protein that in humans is encoded by the WFIKKN2 gene. [1]

Function

The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AY358142.1, AK127743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025083, ERS025084 [ECO:0000348] ##Evidence-Data-END##

See also

References

  1. ↑ "Entrez Gene: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2". Retrieved 2014-03-20.

Further reading

  • Szláma, G; Kondás, K; Trexler, M; Patthy, L (2010). "WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity". FEBS Journal 277 (24): 5040–50. doi:10.1111/j.1742-4658.2010.07909.x. PMID 21054789. 
  • Hill, J. J.; Qiu, Y; Hewick, R. M.; Wolfman, N. M. (2003). "Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: A novel protein with protease inhibitor and follistatin domains". Molecular Endocrinology 17 (6): 1144–54. doi:10.1210/me.2002-0366. PMID 12595574. 
  • Kondás, K; Szláma, G; Trexler, M; Patthy, L (2008). "Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11". Journal of Biological Chemistry 283 (35): 23677–84. doi:10.1074/jbc.M803025200. PMC 3259755. PMID 18596030. 
  • Nagy, A; Trexler, M; Patthy, L (2003). "Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein". European Journal of Biochemistry / FEBS 270 (9): 2101–7. doi:10.1046/j.1432-1033.2003.03593.x. PMID 12709070. 
  • Dieli-Conwright, C. M.; Spektor, T. M.; Rice, J. C.; Sattler, F. R.; Schroeder, E. T. (2012). "Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women". Journal of Strength and Conditioning Research 26 (5): 1374–82. doi:10.1519/JSC.0b013e318251083f. PMID 22395277. 
  • Saremi, A; Gharakhanloo, R; Sharghi, S; Gharaati, M. R.; Larijani, B; Omidfar, K (2010). "Effects of oral creatine and resistance training on serum myostatin and GASP-1". Molecular and Cellular Endocrinology 317 (1–2): 25–30. doi:10.1016/j.mce.2009.12.019. PMID 20026378. 
  • Trexler, M; Bányai, L; Patthy, L (2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biological Chemistry 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID 11928817. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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