ZRANB2

Zinc finger, RAN-binding domain containing 2
PDB rendering based on 1n0z.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1N0Z​, 2K1P​, 3G9Y​
Identifiers
Symbols	ZRANB2 ; ZIS; ZIS1; ZIS2; ZNF265
External IDs	OMIM: 604347 MGI: 1858211 HomoloGene: 135921 GeneCards: ZRANB2 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • RNA binding • protein binding • zinc ion binding • poly(A) RNA binding Cellular component • nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • mRNA processing • RNA splicing Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9406	53861
Ensembl	ENSG00000132485	ENSMUSG00000028180
UniProt	O95218	Q9R020
RefSeq (mRNA)	NM_005455	NM_017381
RefSeq (protein)	NP_005446	NP_059077
Location (UCSC)	Chr 1: 71.06 – 71.08 Mb	Chr 3: 157.53 – 157.55 Mb
PubMed search

Zinc finger Ran-binding domain-containing protein 2 is a protein that in humans is encoded by the ZRANB2 gene.^[1][2]

Interactions

ZRANB2 has been shown to interact with U2 small nuclear RNA auxiliary factor 1^[3] and SNRP70.^[3]

References

1. Nakano M, Yoshiura K, Oikawa M, Miyoshi O, Yamada K, Kondo S, Miwa N, Soeda E, Jinno Y, Fujii T, Niikawa N (February 1999). "Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene". Gene 225 (1–2): 59–65. doi:10.1016/S0378-1119(98)00536-8. PMID 9931435.
2. "Entrez Gene: ZRANB2 zinc finger, RAN-binding domain containing 2".
3. Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (July 2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Adams DJ, van der Weyden L, Kovacic A, Lovicu FJ, Copeland NG, Gilbert DJ, Jenkins NA, Ioannou PA, Morris BJ (2000). "Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene". Cytogenet. Cell Genet. 88 (1–2): 68–73. doi:10.1159/000015487. PMID 10773668.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMC 311086. PMID 11337467.
• Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987.
• Plambeck CA, Kwan AH, Adams DJ, Westman BJ, van der Weyden L, Medcalf RL, Morris BJ, Mackay JP (2003). "The structure of the zinc finger domain from human splicing factor ZNF265 fold". J. Biol. Chem. 278 (25): 22805–22811. doi:10.1074/jbc.M301896200. PMID 12657633.
• Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–7447. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Mangs AH, Speirs HJ, Goy C, Adams DJ, Markus MA, Morris BJ (2006). "XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265". Nucleic Acids Res. 34 (17): 4976–4986. doi:10.1093/nar/gkl660. PMC 1635291. PMID 16982639.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• ZRANB2 human gene location in the UCSC Genome Browser.
• ZRANB2 human gene details in the UCSC Genome Browser.