Zinc gluconate

Zinc gluconate

Identifiers
CAS Number	4468-02-4
ChemSpider	391659
Jmol interactive 3D	Image
InChI InChI=1S/2C6H12O7.Zn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1 Key: WHMDKBIGKVEYHS-IYEMJOQQSA-L InChI=1/2C6H12O7.Zn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1 Key: WHMDKBIGKVEYHS-QFKJHGNTBI
SMILES [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[O-]C(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
Properties
Chemical formula	C12H22O14Zn
Molar mass	455.685 g/mol
Melting point	172 to 175 °C (342 to 347 °F; 445 to 448 K)
Pharmacology
ATC code	A12CB02
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Zinc gluconate (also called zincum gluconicum) is the zinc salt of gluconic acid. It is an ionic compound consisting of two moles of gluconate for each mole of zinc. Zinc gluconate is a popular form for the delivery of zinc as a dietary supplement.

Gluconic acid is found naturally, and is industrially manufactured by the fermentation of glucose, typically by Aspergillus niger, but also by other fungi, e.g. Penicillium, or by bacteria, e.g. Acetobacter, Pseudomonas and Gluconobacter.^[1] In its pure form, it is a white to off-white powder. It can also be manufactured by electrolytic oxidation,^[2] although this is a more expensive process. The advantages are a lower microbiological profile, and a more complete reaction, yielding a product with a longer shelf life.

Zinc gluconate and the common cold

Zinc gluconate has been used in lozenges for treating the common cold. However, controlled trials with lozenges composed of zinc acetate have found the greatest effect on the duration of colds.^[3][4][5]

Zinc has also been administered nasally for treating the common cold, but anosmia has been claimed to be caused by such treatment (see below).

Safety concerns

Instances of anosmia (loss of smell) have been reported with intranasal use of some products containing zinc gluconate. In September 2003, Zicam faced lawsuits from users who claimed that the product, a nasal gel containing zinc gluconate and several inactive ingredients, negatively affected their sense of smell and sometimes taste. Some plaintiffs alleged experiencing a strong and very painful burning sensation when they used the product. Matrixx Initiatives, Inc., the maker of Zicam, responded that only a small number of people had experienced problems and that anosmia can be caused by the common cold itself. In January 2006, 340 lawsuits were settled for $12 million.^[6]

The U.S. Food and Drug Administration (FDA) considers zinc gluconate to be generally recognized as safe (GRAS) when used in accordance with good manufacturing practice, although this does not constitute a finding by the FDA that the substance is a useful dietary supplement.^[7] On 16 June 2009 the FDA "warned consumers to stop using and discard three zinc-containing Zicam intranasal products. The products may cause a loss of sense of smell. ... FDA is concerned that the loss of sense of smell may be permanent." ^[8][9] Matrixx responded that the FDA's allegations were "unfounded and misleading", citing a lack of evidence from controlled tests that Zicam causes anosmia.^[10] In its warning, FDA stated, "This warning does not involve oral zinc tablets and lozenges taken by mouth. Dietary zinc is also not subject to this warning." ^[8]

See also

• Neutersol, a veterinary chemical castration drug containing Zinc Gluconate

References

1. Sumitra Ramachandran, Pierre Fontanille, Ashok Pandey and Christian Larroche (2006). "Gluconic Acid: A Review" (PDF). Food Technology and Biotechnology 44 (2): 185–195. Retrieved 2006-12-06.
2. Henk G.J. de Wilt (1972). "Part I: The oxidation of Glucose to Gluconic Acid". Ind. Eng. Chem. Prod. Res. Develop. 11 (4): 370. doi:10.1021/i360044a002. Retrieved 2006-12-06.
3. Hemilä H (2011) Zinc lozenges may shorten the duration of colds: a systematic review. Open Respir Med J 5:51-8 Refs with links: http://www.mv.helsinki.fi/home/hemila/Zn/TORMJ.htm
4. Eby GA (2004) Zinc lozenges: cold cure or candy? Solution chemistry determinations. Biosci Rep 24:23-39
5. Eby GA (2010) Zinc lozenges as cure for the common cold. Med Hypotheses 74:482-92
6. zicam.vanosteen.com
7. "Title 21, Part 182 Substances Generally Recognized as Safe (21CFR182)". United States Code of Federal Regulations. Food and Drug Administration, Department of Health and Human Services. Retrieved 2007-07-09.
8. http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm166931.htm Retrieved on 2009-07-18
9. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm167065.htm Retrieved on 2009-07-18
10. "FDA warns against using 3 popular Zicam cold meds". CNN. 2009-06-16. Retrieved 2010-04-29.

External links

• A12CB02