Zofenopril

Zofenopril

Systematic (IUPAC) name
(2S,4S)-1-[(2S)-3-benzoylsulfanyl-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
Identifiers
CAS Number	81872-10-8
ATC code	C09AA15 (WHO)
PubChem	CID 92400
IUPHAR/BPS	6462
ChemSpider	83422
UNII	290ZY759PI
KEGG	D08688
ChEBI	CHEBI:78539
ChEMBL	CHEMBL331378
Chemical data
Formula	C22H23NO4S2
Molar mass	429.552 g/mol
SMILES O=C(N2[C@H](C(=O)O)C[C@H](Sc1ccccc1)C2)[C@H](C)CSC(=O)c3ccccc3
InChI InChI=1S/C22H23NO4S2/c1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,25,26)/t15-,18+,19+/m1/s1 Key:IAIDUHCBNLFXEF-MNEFBYGVSA-N
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Zofenopril (also known as zofenoprilum [Latin]) is an angiotensin converting enzyme (ACE) inhibitor with cardioprotective properties indicated for the treatment of hypertension.^[1]

In small studies, zofenopril appeared significantly more effective than the older antihypertensives atenolol and enalapril, and was associated with fewer adverse effects.^[2][3]

Zofenoprilat — the active metabolite of zofenopril

References

1. Ambrosioni E (2007). "Defining the role of zofenopril in the management of hypertension and ischemic heart disorders". Am J Cardiovasc Drugs 7 (1): 17–24. doi:10.2165/00129784-200707010-00002. PMID 17355163.
2. Nilsson P (October 2007). "Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension". Blood Press Suppl 2: 25–30. PMID 18046976.
3. Mallion JM (October 2007). "An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension". Blood Press Suppl 2: 13–8. PMID 18046974.