(Pyruvate, phosphate dikinase)-phosphate phosphotransferase

(Pyruvate, phosphate dikinase)-phosphate phosphotransferase (EC 2.7.4.27, PPDK regulatory protein, pyruvate, phosphate dikinase regulatory protein, bifunctional dikinase regulatory protein, PDRP1 (gene)) is an enzyme with systematic name (pyruvate, phosphate dikinase) phosphate:phosphate phosphotransferase.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

[pyruvate, phosphate dikinase] phosphate + phosphate

\rightleftharpoons

[pyruvate, phosphate dikinase] + diphosphate

The enzyme from the plants maize and arabidopsis is bifunctional and also catalyses the phosphorylation of pyruvate.

References

↑ Burnell, J.N. and Hatch, M.D. (1984). "Regulation of C₄ photosynthesis: identification of a catalytically important histidine residue and its role in the regulation of pyruvate,P_i dikinase". Arch. Biochem. Biophys. 231: 175–182. doi:10.1016/0003-9861(84)90375-8. PMID 6326674.
↑ Burnell, J.N. and Hatch, M.D. (1985). "Regulation of C₄ photosynthesis: purification and properties of the protein catalyzing ADP-mediated inactivation and P_i-mediated activation of pyruvate,P_i dikinase". Arch. Biochem. Biophys. 237: 490–503. doi:10.1016/0003-9861(85)90302-9. PMID 2983615.
↑ Chastain, C.J., Botschner, M., Harrington, G.E., Thompson, B.J., Mills, S.E., Sarath, G. and Chollet, R. (2000). "Further analysis of maize C₄ pyruvate,orthophosphate dikinase phosphorylation by its bifunctional regulatory protein using selective substitutions of the regulatory Thr-456 and catalytic His-458 residues". Arch. Biochem. Biophys. 375: 165–170. doi:10.1006/abbi.1999.1651. PMID 10683263.
↑ Burnell, J.N. and Chastain, C.J. (2006). "Cloning and expression of maize-leaf pyruvate, P_i dikinase regulatory protein gene". Biochem. Biophys. Res. Commun. 345: 675–680. doi:10.1016/j.bbrc.2006.04.150. PMID 16696949.
↑ Chastain, C.J., Xu, W., Parsley, K., Sarath, G., Hibberd, J.M. and Chollet, R. (2008). "The pyruvate, orthophosphate dikinase regulatory proteins of Arabidopsis possess a novel, unprecedented Ser/Thr protein kinase primary structure". Plant J. 53: 854–863. doi:10.1111/j.1365-313x.2007.03366.x. PMID 17996018.

External links

(pyruvate, phosphate dikinase)-phosphate phosphotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO₄)

2.7.1: OH acceptor	Hexo- Gluco- Fructo- Hepatic Galacto- Phosphofructo- 1 Liver Muscle Platelet 2 Riboflavin Shikimate Thymidine ADP-thymidine NAD⁺ Glycerol Pantothenate Mevalonate Pyruvate Deoxycytidine PFP Diacylglycerol Phosphoinositide 3 Class I PI 3 Class II PI 3 Sphingosine Glucose-1,6-bisphosphate synthase

2.7.2: COOH acceptor	Phosphoglycerate Aspartate kinase

2.7.3: N acceptor	Creatine

2.7.4: PO₄ acceptor	Phosphomevalonate Adenylate Nucleoside-diphosphate Uridylate Guanylate Thiamine-diphosphate

2.7.6: diphosphotransferase
(P₂O₇)

2.7.7: nucleotidyltransferase
(PO₄-nucleoside)

Polymerase

DNA polymerase	DNA-directed DNA polymerase I II III IV V RNA-directed DNA polymerase Reverse transcriptase Telomerase DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase

RNA nucleotidyltransferase	RNA polymerase/DNA-directed RNA polymerase RNA polymerase I RNA polymerase II RNA polymerase III RNA polymerase IV Primase RNA-dependent RNA polymerase PNPase

Phosphorolytic
3' to 5' exoribonuclease

Nucleotidyltransferase

Guanylyltransferase

mRNA capping enzyme

Other

2.7.8: miscellaneous

Phosphatidyltransferases	CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase CDP-diacylglycerol—serine O-phosphatidyltransferase CDP-diacylglycerol—inositol 3-phosphatidyltransferase CDP-diacylglycerol—choline O-phosphatidyltransferase

Glycosyl-1-phosphotransferase	N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(PO₄; protein acceptor)

2.7.10: protein-tyrosine	see tyrosine kinases

2.7.11: protein-serine/threonine	see serine/threonine-specific protein kinases

2.7.12: protein-dual-specificity	see serine/threonine-specific protein kinases

2.7.13: protein-histidine	Protein-histidine pros-kinase Protein-histidine tele-kinase Histidine kinase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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