1-Decanol

1-Decanol[1]
Names
IUPAC name
Decan-1-ol
Other names
decyl alcohol
n-decyl alcohol
capric alcohol
epal 10
antak
agent 504
Identifiers
112-30-1 YesY
ChEBI CHEBI:28903 YesY
ChEMBL ChEMBL25363 YesY
ChemSpider 7882 YesY
Jmol interactive 3D Image
KEGG C01633 YesY
PubChem 8174
UNII 89V4LX791F YesY
Properties
C10H22O
Molar mass 158.28 g/mol
Appearance Viscous liquid
Density 0.8297 g/cm3
Melting point 6.4 °C (43.5 °F; 279.5 K)
Boiling point 232.9 °C (451.2 °F; 506.0 K)
3.7 g/L at 20°C[2]
log P 4.57
Viscosity 12.048 mPa.s (@ 25 °C)
Hazards
Safety data sheet Oxford MSDS
Flash point 108 °C (226 °F; 381 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

1-Decanol is a straight chain fatty alcohol with ten carbon atoms and the molecular formula C10H21OH. It is a colorless to light yellow viscous liquid that is insoluble in water and has an aromatic odor.[3] The interfacial tension against water at 20 °C is 8.97 mN/m.

Production

Decanol can be prepared by the hydrogenation of decanoic acid, which occurs in modest quantities in coconut oil (about 10%) and palm kernel oil (about 4%). It may also be produced synthetically via the Ziegler process.

Uses

Decanol is used in the manufacture of plasticizers, lubricants, surfactants and solvents. Its ability to permeate the skin has led to it being investigated as a penetration enhancer for transdermal drug delivery.[4][5]

Safety

Like other medium chain fatty alcohols, 1-decanol is able to permeate the skin which can lead to irritation.

References

  1. Merck Index, 12th Edition, 2911.
  2. http://www.cdc.gov/niosh/ipcsneng/neng1490.html
  3. "SAFETY DATA SHEET". Acros Organics. Retrieved 23 April 2015.
  4. Kanikkannan, N; Singh, Mandip (November 2002). "Skin permeation enhancement effect and skin irritation of saturated fatty alcohols". International Journal of Pharmaceutics 248 (1-2): 219–228. doi:10.1016/S0378-5173(02)00454-4.
  5. Williams, Adrian C; Barry, Brian W (March 2004). "Penetration enhancers". Advanced Drug Delivery Reviews 56 (5): 603–618. doi:10.1016/j.addr.2003.10.025.
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