| 2014–15 Game Log Record: 23–49–8 (Home: 14–21–5 ; Road: 9–28–3)
 | 
| 
| October: 2–8–1 (Home: 0–4–1 ; Road: 2–4–0) |  
| # | Date | Visitor | Score | Home | OT | Decision | Attendance | Record | Pts | Recap |  
| 1 | October 9 | Columbus | 3–1 | Buffalo |  | Enroth | 18,215 | 0–1–0 | 0 | Recap |  
| 2 | October 11 | Buffalo | 2–6 | Chicago |  | Enroth | 22,012 | 0–2–0 | 0 | Recap |  
| 3 | October 13 | Anaheim | 5–1 | Buffalo |  | Neuvirth | 18,912 | 0–3–0 | 0 | Recap |  
| 4 | October 14 | Buffalo | 4–3 | Carolina | SO | Enroth | 14,930 | 1–3–0 | 2 | Recap |  
| 5 | October 17 | Florida | 1–0 | Buffalo |  | Enroth | 17,864 | 1–4–0 | 2 | Recap |  
| 6 | October 18 | Boston | 4–0 | Buffalo |  | Enroth | 18,685 | 1–5–0 | 2 | Recap |  
| 7 | October 22 | Buffalo | 1–4 | Anaheim |  | Neuvirth | 16,067 | 1–6–0 | 2 | Recap |  
| 8 | October 23 | Buffalo | 0–2 | Los Angeles |  | Enroth | 18,230 | 1–7–0 | 2 | Recap |  
| 9 | October 25 | Buffalo | 2–1 | San Jose |  | Neuvirth | 17,370 | 2–7–0 | 4 | Recap |  
| 10 | October 28 | Buffalo | 0–4 | Toronto |  | Neuvirth | 18,898 | 2–8–0 | 4 | Recap |  
| 11 | October 30 | Boston | 3–2 | Buffalo | OT | Enroth | 17,477 | 2–8–1 | 5 | Recap |  | 
| 
| November: 6–6–1 (Home: 4–3–1 ; Road: 2–3–0) |  
| # | Date | Visitor | Score | Home | OT | Decision | Attendance | Record | Pts | Recap |  
| 12 | November 1 | Buffalo | 0–5 | Pittsburgh |  | Enroth | 18,652 | 2–9–1 | 5 | Recap |  
| 13 | November 2 | Detroit | 2–3 | Buffalo | SO | Neuvirth | 17,815 | 3–9–1 | 7 | Recap |  
| 14 | November 5 | Montreal | 2–1 | Buffalo | SO | Neuvirth | 17,837 | 3–9–2 | 8 | Recap |  
| 15 | November 7 | Edmonton | 3–2 | Buffalo |  | Neuvirth | 17,490 | 3–10–2 | 8 | Recap |  
| 16 | November 8 | Pittsburgh | 6–1 | Buffalo |  | Enroth | 19,070 | 3–11–2 | 8 | Recap |  
| 17 | November 11 | Buffalo | 1–6 | St. Louis |  | Neuvirth | 17,570 | 3–12–2 | 8 | Recap |  
| 18 | November 13 | Buffalo | 3–6 | Minnesota |  | Enroth | 18,925 | 3–13–2 | 8 | Recap |  
| 19 | November 15 | Toronto | 2–6 | Buffalo |  | Neuvirth | 19,070 | 4–13–2 | 10 | Recap |  
| 20 | November 18 | San Jose | 1–4 | Buffalo |  | Enroth | 17,435[8] | 5–13–2 | 12 | Recap |  
| – | November 21 | NY Rangers |  | Buffalo | Game rescheduled to February 20 due to hazardous weather in Buffalo. |  
| 21 | November 22 | Buffalo | 2–1 | Washington |  | Enroth | 18,506 | 6–13–2 | 14 | Recap |  
| 22 | November 26 | Winnipeg | 2–1 | Buffalo |  | Enroth | 18,442 | 6–14–2 | 14 | Recap |  
| 23 | November 28 | Montreal | 1–2 | Buffalo |  | Enroth | 19,070 | 7–14–2 | 16 | Recap |  
| 24 | November 29 | Buffalo | 4–3 | Montreal | SO | Enroth | 21,287 | 8–14–2 | 18 | Recap |  | 
| 
| December: 6–7–1 (Home: 6–2–0 ; Road: 0–5–1) |  
| # | Date | Visitor | Score | Home | OT | Decision | Attendance | Record | Pts | Recap |  
| 25 | December 2 | Tampa Bay | 1–2 | Buffalo | SO | Enroth | 17,772 | 9–14–2 | 20 | Recap |  
| 26 | December 4 | Buffalo | 0–5 | Tampa Bay |  | Enroth | 17,767 | 9–15–2 | 20 | Recap |  
| 27 | December 6 | Buffalo | 2–3 | Florida |  | Neuvirth | 8,597 | 9–16–2 | 20 | Recap |  
| 28 | December 9 | Los Angeles | 0–1 | Buffalo |  | Enroth | 18,438 | 10–16–2 | 22 | Recap |  
| 29 | December 11 | Calgary | 3–4 | Buffalo |  | Enroth | 18,208 | 11–16–2 | 24 | Recap |  
| 30 | December 13 | Florida | 3–4 | Buffalo | OT | Enroth | 18,450 | 12–16–2 | 26 | Recap |  
| 31 | December 15 | Ottawa | 4–5 | Buffalo | SO | Enroth | 14,578 | 13–16–2 | 28 | Recap |  
| 32 | December 16 | Buffalo | 1–5 | Winnipeg |  | Neuvirth | 15,016 | 13–17–2 | 28 | Recap |  
| 33 | December 20 | Colorado | 5–1 | Buffalo |  | Enroth | 18,831 | 13–18–2 | 28 | Recap |  
| 34 | December 21 | Buffalo | 3–4 | Boston | OT | Enroth | 17,565 | 13–18–3 | 29 | Recap |  
| 35 | December 23 | Buffalo | 3–6 | Detroit |  | Neuvirth | 20,027 | 13–19–3 | 29 | Recap |  
| 36 | December 27 | NY Islanders | 3–4 | Buffalo | SO | Enroth | 19,070 | 14–19–3 | 31 | Recap |  
| 37 | December 29 | Buffalo | 2–5 | Ottawa |  | Enroth | 18,284 | 14–20–3 | 31 | Recap |  
| 38 | December 31 | Tampa Bay | 5–1 | Buffalo |  | Enroth | 19,070 | 14–21–3 | 31 | Recap |  | 
| 
| January: 0–12–0 (Home: 0–4–0 ; Road: 0–8–0) |  
| # | Date | Visitor | Score | Home | OT | Decision | Attendance | Record | Pts | Recap |  
| 39 | January 2 | Florida | 2–0 | Buffalo |  | Neuvirth | 19,070 | 14–22–3 | 31 | Recap |  
| 40 | January 3 | Buffalo | 1–6 | NY Rangers |  | Neuvirth | 18,006 | 14–23–3 | 31 | Recap |  
| 41 | January 6 | Buffalo | 1–4 | New Jersey |  | Enroth | 15,162 | 14–24–3 | 31 | Recap |  
| 42 | January 8 | Buffalo | 2–5 | Carolina |  | Enroth | 9,781 | 14–25–3 | 31 | Recap |  
| 43 | January 9 | Buffalo | 1–2 | Tampa Bay |  | Neuvirth | 19,204 | 14–26–3 | 31 | Recap |  
| 44 | January 13 | Detroit | 3–1 | Buffalo |  | Neuvirth | 19,070 | 14–27–3 | 31 | Recap |  
| 45 | January 15 | Minnesota | 7–0 | Buffalo |  | Enroth | 18,963 | 14–28–3 | 31 | Recap |  
| 46 | January 17 | Philadelphia | 4–3 | Buffalo |  | Neuvirth | 19,070 | 14–29–3 | 31 | Recap |  
| 47 | January 18 | Buffalo | 4–6 | Detroit |  | Enroth | 20,027 | 14–30–3 | 31 | Recap |  
| 48 | January 27 | Buffalo | 1–4 | Calgary |  | Enroth | 18,563 | 14–31–3 | 31 | Recap |  
| 49 | January 29 | Buffalo | 2–3 | Edmonton |  | Enroth | 16,839 | 14–32–3 | 31 | Recap |  
| 50 | January 30 | Buffalo | 2–5 | Vancouver |  | Hackett | 18,570 | 14–33–3 | 31 | Recap |  | 
| 
| February: 5–6–2 (Home: 2–5–1 ; Road: 3–1–1) |  
| # | Date | Visitor | Score | Home | OT | Decision | Attendance | Record | Pts | Recap |  
| 51 | February 3 | Buffalo | 3–2 | Montreal |  | Enroth | 21,286 | 15–33–3 | 33 | Recap |  
| 52 | February 5 | St. Louis | 3–0 | Buffalo |  | Enroth | 18,912 | 15–34–3 | 33 | Recap |  
| 53 | February 7 | Dallas | 2–3 | Buffalo |  | Enroth | 18,426 | 16–34–3 | 35 | Recap |  
| 54 | February 8 | NY Islanders | 3–2 | Buffalo |  | Neuvirth | 18,900 | 16–35–3 | 35 | Recap |  
| 55 | February 10 | Ottawa | 2–1 | Buffalo |  | Enroth | 19,070 | 16–36–3 | 35 | Recap |  
| 56 | February 15 | Philadelphia | 2–1 | Buffalo |  | Neuvirth | 18,759 | 16–37–3 | 35 | Recap |  
| 57 | February 17 | Buffalo | 1–2 | New Jersey | SO | Neuvirth | 13,517 | 16–37–4 | 36 | Recap |  
| 58 | February 19 | Buffalo | 3–2 | Philadelphia | SO | Neuvirth | 19,472 | 17–37–4 | 38 | Recap |  
| 59 | February 20 | NY Rangers | 3–1 | Buffalo |  | Neuvirth | 19,070 | 17–38–4 | 38 | Recap |  
| 60 | February 22 | Nashville | 2–1 | Buffalo | SO | Neuvirth | 19,070 | 17–38–5 | 39 | Recap |  
| 61 | February 24 | Buffalo | 4–2 | Columbus |  | Neuvirth | 13,671 | 18–38–5 | 41 | Recap |  
| 62 | February 26 | Vancouver | 3–6 | Buffalo |  | Neuvirth | 19,070 | 19–38–5 | 43 | Recap |  
| 63 | February 28 | Buffalo | 3–5 | Florida |  | Neuvirth | 10,374 | 19–39–5 | 43 | Recap |  | 
| 
| March: 2–8–3 (Home: 0–2–2 ; Road: 2–6–1) |  
| # | Date | Visitor | Score | Home | OT | Decision | Attendance | Record | Pts | Recap |  
| 64 | March 3 | Buffalo | 0–3 | Tampa Bay |  | Lindback | 18,922 | 19–40–5 | 43 | Recap |  
| 65 | March 6 | Buffalo | 2–3 | Ottawa |  | Lindback | 18,241 | 19–41–5 | 43 | Recap |  
| 66 | March 7 | Buffalo | 1–6 | Washington |  | Hackett | 18,506 | 19–42–5 | 43 | Recap |  
| 67 | March 11 | Buffalo | 3–4 | Toronto | SO | Lindback | 18,844 | 19–42–6 | 44 | Recap |  
| 68 | March 14 | NY Rangers | 2–0 | Buffalo |  | Lindback | 19,070 | 19–43–6 | 44 | Recap |  
| 69 | March 16 | Washington | 4–3 | Buffalo | SO | Lindback | 19,070 | 19–43–7 | 45 | Recap |  
| 70 | March 17 | Buffalo | 2–1 | Boston | SO | Lindback | 17,565 | 20–43–7 | 47 | Recap |  
| 71 | March 20 | New Jersey | 3–1 | Buffalo |  | Lindback | 19,070 | 20–44–7 | 47 | Recap |  
| 72 | March 21 | Buffalo | 0–3 | Nashville |  | Hackett | 17,113 | 20–45–7 | 47 | Recap |  
| 73 | March 23 | Buffalo | 3–4 | Dallas |  | Lindback | 18,113 | 20–46–7 | 47 | Recap |  
| 74 | March 26 | Arizona | 4–3 | Buffalo | OT | Hackett | 19,070 | 20–46–8 | 48 | Recap |  
| 75 | March 28 | Buffalo | 3–5 | Colorado |  | Hackett | 18,007 | 20–47–8 | 48 | Recap |  
| 76 | March 30 | Buffalo | 4–1 | Arizona |  | Lindback | 13,612 | 21–47–8 | 50 | Recap |  | 
| 
| April: 2–4–0 (Home: 2–2–0 ; Road: 0–2–0) |  
| # | Date | Visitor | Score | Home | OT | Decision | Attendance | Record | Pts | Recap |  
| 77 | April 1 | Toronto | 3–4 | Buffalo |  | Lindback | 19,070 | 22–47–8 | 52 | Recap |  
| 78 | April 3 | Chicago | 3–4 | Buffalo |  | Lindback | 19,070 | 22–48–8 | 52 | Recap |  
| 79 | April 4 | Buffalo | 0–3 | NY Islanders |  | Makarov | 16,170 | 22–49–8 | 52 | Recap |  
| 80 | April 6 | Carolina | 3–4 | Buffalo |  | Lindback | 19,070 | 23–49–8 | 54 | Recap |  
| 81 | April 10 | Buffalo | 2–4 | Columbus |  | Lindback | 17,855 | 23–50–8 | 54 | Recap |  
| 82 | April 11 | Pittsburgh | 2–0 | Buffalo |  | Lindback | 19,070 | 23–51–8 | 54 | Recap |  | 
| Legend:
      Win (2 points)
      Loss (0 points)
      Overtime/shootout loss (1 point) |