27S pre-rRNA (guanosine2922-2'-O)-methyltransferase

27S pre-rRNA (guanosine²⁹²²-2'-O)-methyltransferase (EC 2.1.1.167, Spb1p (gene), YCL054W (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:27S pre-rRNA (guanosine²⁹²²-2'-O-)-methyltransferase.^[1]^[2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanosine²⁹²² in 27S pre-rRNA

\rightleftharpoons

S-adenosyl-L-homocysteine + 2'-O-methylguanosine²⁹²² in 27S pre-rRNA

Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922.

References

↑ Lapeyre, B. and Purushothaman, S.K. (2004). "Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage". Mol. Cell 16 (4): 663–669. doi:10.1016/j.molcel.2004.10.022. PMID 15546625.
↑ Bonnerot, C., Pintard, L. and Lutfalla, G. (2003). "Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2′-O-ribose methylation of a conserved rRNA position in yeast". Mol. Cell 12 (5): 1309–1315. doi:10.1016/S1097-2765(03)00435-0. PMID 14636587.

External links

27S pre-rRNA (guanosine2922-2'-O)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase

O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase

Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase

Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase

Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase

Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase

Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

2.1.4: Amidine

Arginine:glycine amidinotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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