Diiodotyrosine
Not to be confused with diiodothyronine.
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| Identifiers | |
|---|---|
66-02-4  | |
| ChemSpider | 8946  |
| 6651 | |
| Jmol interactive 3D | Image |
| MeSH | Diiodotyrosine |
| PubChem | 6181 7058163 |
| UNII | 6L57Q44ZWW |
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| Properties | |
| C9H9I2NO3 | |
| Molar mass | 432.982 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| verify (what is ?) | |
| Infobox references | |
Diiodotyrosine (DIT) is a precursor in the production of thyroid hormone, and results from iodization of monoiodotyrosine at the other meta- position on the phenol ring.
Function
DIT is a modulator of the enzyme thyroid peroxidase (which is involved in the production of thyroid hormones).[1]
Triiodothyronine is formed, when diiodotyrosine is combined with monoiodotyrosine (in the colloid of the thyroid follicle).
Two molecules of DIT combine to make the thyroid hormone thyroxine ('T4' and 'T3').
See also
References
- ↑ Dème D, Fimiani E, Pommier J, Nunez J (February 1975). "Free diiodotyrosine effects on protein iodination and thyroid hormone synthesis catalyzed by thyroid peroxidase". Eur. J. Biochem. 51 (2): 329–36. doi:10.1111/j.1432-1033.1975.tb03932.x. PMID 1149735.
External links
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