Diiodotyrosine transaminase

Thus, the two substrates of this enzyme are 3,5-diiodo-L-tyrosine and 2-oxoglutarate, whereas its two products are 4-hydroxy-3,5-diiodophenylpyruvate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase. Other names in common use include diiodotyrosine aminotransferase, halogenated tyrosine aminotransferase, and halogenated tyrosine transaminase. It employs one cofactor, pyridoxal phosphate.

References

Nakano M (1967). "Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney mitochondria". J. Biol. Chem. 242 (1): 73–81. PMID 4381052.
Nakano M and Danowski TS (1964). "Thyroid-hormone transaminase and oxidase in rat-kidney mitochondria". Biochim. Biophys. Acta 85: 18–28. doi:10.1016/0926-6569(64)90163-4. PMID 14159298.

Thyroid hormone metabolism enzymes and transporters

Enzymes	Thyroid peroxidase Iodotyrosine deiodinase Dual oxidase 1/Dual oxidase 2 Iodothyronine deiodinase Diiodotyrosine transaminase

Transporters	Monocarboxylate transporter 8\|Monocarboxylate transporter 8 (MCT8) Sodium-iodide symporter Pendrin

Transferase: nitrogenous groups (EC 2.6)

2.6.1: Transaminases	Aspartate transaminase GOT1 GOT2 Alanine transaminase GABA transaminase Tyrosine aminotransferase Ornithine aminotransferase Branched chain aminotransferase Alanine—glyoxylate transaminase AGXT

2.6.3: Oximinotransferases	Oximinotransferase

2.6.99: Other	Pyridoxine 5'-phosphate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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